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Type: Journal article
Title: A pharmacokinetic and phase II study of gallium nitrate in patients with non-small cell lung cancer
Author: Webster, L.
Olver, I.
Stokes, K.
Sephton, R.
Hillcoat, B.
Bishop, J.
Citation: Cancer Chemotherapy and Pharmacology, 2000; 45(1):55-58
Publisher: Springer
Issue Date: 2000
ISSN: 0344-5704
Statement of
Lorraine K. Webster, Ian N. Olver, Kerrie H. Stokes, Robert G. Sephton, Brian L. Hillcoat, James F. Bishop
Abstract: This study investigated the pharmacokinetics and activity of gallium nitrate in non-small cell lung cancer when 700 mg/m2 was given as a 30-min infusion with prehydration every 2 weeks. Gallium was measured in plasma and urine using flameless atomic absorption spectrophotometry, and pharmacokinetics of total and ultrafilterable gallium were calculated. Twenty-five patients with non-small cell lung cancer received 1-12 (median 2) courses of gallium nitrate every 2 weeks. Of 21 patients evaluable for response, 1 partial response was recorded, 4 patients had stable disease. and 16 had progressed. The most serious toxicities were renal impairment and optic neuritis. Hypocalcaemia was recorded in 3 patients. The mean C(max) was 15.2 +/- 3.1 microg/ ml (range 9.5-21.2). Most gallium remained ultrafilterable for the first 10 h, after which plasma protein binding increased, and at 48 h only 11% was present as ultrafilterable gallium. The elimination profiles of both total and ultrafilterable gallium were biphasic, and the distribution phase consisted of ultrafilterable gallium, with a distribution half-life of 1.4 h. Total gallium plateaued at 1.9 microg/ml at between 8 and 12 h, and the estimated elimination half-life was 63 h. The elimination half-life of ultrafilterable gallium was 16.5 h. Inter- and intra-patient variability in pharmacokinetics was minimal. A mean of 50 +/- 14% of the gallium dose was excreted in the urine within 48 h. A short infusion of gallium nitrate achieving high peak plasma concentrations results in little efficacy in non-small cell lung cancer.
Keywords: Humans; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Gallium; Transferrin; Antineoplastic Agents; Adult; Aged; Middle Aged; Female; Male
RMID: 0001001243
DOI: 10.1007/PL00006743
Appears in Collections:Medicine publications

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