Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/93566
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Type: Journal article
Title: Dietary long-chain polyunsaturated fatty acids do not influence growth of term infants: A randomized clinical trial
Author: Makrides, M.
Neumann, M.
Simmer, K.
Gibson, R.
Citation: Pediatrics, 1999; 104(3):468-475
Publisher: American Academy of Pediatrics
Issue Date: 1999
ISSN: 1098-4275
0031-4005
Statement of
Responsibility: 
Maria Makrides, Mark A. Neumann, Karen Simmer, and Robert A. Gibson
Abstract: OBJECTIVE: To determine if dietary long-chain polyunsaturated fatty acids (LCPUFA) affect the growth of formula-fed infants relative to breastfed infants. METHODS: A randomized, double-blind trial of three formula-fed groups and a parallel reference group of breastfed infants was conducted. The three treatments were a placebo (no LCPUFA), docosahexaenoic acid (DHA) supplemented, and DHA plus arachidonic acid supplemented formulas fed for 12 months. Infant weight, length, head circumference, and fatty acid status were assessed at 6, 16, 34 weeks, and 1 year of age. Anthropometrics were repeated at 2 years of age. RESULTS: There were no differences between the randomized formula groups for weight, length, or head circumference even after adjustment for gender, gestational age, and the actual age at assessment. Post hoc regressions demonstrated a small negative association between DHA status at 16 weeks of age and weight at 1 and 2 years. CONCLUSIONS: Dietary LCPUFA do not influence growth of healthy term infants to a clinically significant degree.
Keywords: docosahexaenoic acid; arachidonic acid; growth; infants; breast milk; infant formula; long-chain polyunsaturated fatty acids
Rights: Copyright © 1999 by the American Academy of Pediatrics
DOI: 10.1542/peds.104.3.468
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