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https://hdl.handle.net/2440/9372
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Type: | Journal article |
Title: | Successful salvage of RAEB/AML relapsing early post allograft with FLAG-Ida conditioned mini-allograft: a report of two cases |
Author: | Hui, C. Bardy, P. Hughes, T. Horvath, N. To, L. |
Citation: | International Journal of Laboratory Hematology, 2001; 23(2):135-138 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2001 |
ISSN: | 1751-5521 0141-9854 |
Statement of Responsibility: | C.H. Hui, P. Bardy, T. Hughes, N. Horvath, L.B. To |
Abstract: | Management options are often limited for patients with AML or high grade myelodysplasia (MDS) relapsing within a year of allogeneic transplantation. We report, in two such patients, the use of re-induction with FLAG-Ida chemotherapy, followed by the infusion of GCSF-mobilized blood stem cells from the same HLA-matched donor. Both patients achieved durable complete remissions with good quality of life and longer disease-free survival than after the first myeloablative allografts. This mini-allograft approach offers a practical, well-tolerated salvage and a potentially curative treatment for relapsed AML/high grade MDS patients failing a first conventional myeloablative allogeneic transplants. |
Keywords: | Humans Anemia, Refractory, with Excess of Blasts Recurrence Idarubicin Filgrastim Granulocyte Colony-Stimulating Factor Recombinant Proteins Cytarabine Vidarabine Antineoplastic Combined Chemotherapy Protocols Salvage Therapy Hematopoietic Stem Cell Transplantation Transplantation, Homologous Middle Aged Female Leukemia, Myeloid, Acute |
Description: | The definitive version may be found at www.wiley.com |
Provenance: | Published Online: 20 Dec 2001 |
Rights: | Copyright © 2001 Blackwell Science Limited |
DOI: | 10.1046/j.1365-2257.2001.00359.x |
Published version: | http://dx.doi.org/10.1046/j.1365-2257.2001.00359.x |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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