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https://hdl.handle.net/2440/9382
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dc.contributor.author | Chapman, M. | - |
dc.contributor.author | Fraser, R. | - |
dc.contributor.author | Kluger, M. | - |
dc.contributor.author | Buist, M. | - |
dc.contributor.author | De Nichilo, D. | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Critical Care Medicine, 2000; 28(7):2334-2337 | - |
dc.identifier.issn | 0090-3493 | - |
dc.identifier.issn | 1530-0293 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9382 | - |
dc.description.abstract | <h4>Objective</h4>To evaluate the effect of intravenous erythromycin on gastric emptying and the success of enteral feeding in mechanically ventilated, critically ill patients with large volume gastric aspirates.<h4>Design</h4>Prospective, double-blind, randomized, and placebo-controlled trial.<h4>Setting</h4>General intensive care unit in a university hospital.<h4>Patients</h4>Twenty critically ill, mechanically ventilated patients intolerant of nasogastric feeding (indicated by a residual gastric volume of > or =250 mL during feed administration at > or =40 mL/hr).<h4>Interventions</h4>After a gastric aspirate of > or =250 mL, which was discarded, the enteral feeding was continued at the previous rate for 3 hrs. Intravenous erythromycin (200 mg) or placebo was then administered over 20 mins. The residual gastric contents were again aspirated and the volume was recorded 1 hr after the infusion began.<h4>Measurements and main results</h4>Gastric emptying was calculated as volume of feed infused into the stomach over 4 hrs minus the residual volume aspirated. Mean gastric emptying was 139+/-37 (+/-SEM) mL after erythromycin and -2+/-46 mL after placebo (p = .027). Nasogastric feeding was successful in nine of ten patients treated with erythromycin and five of ten who received placebo 1 hr after infusion (chi-square p = .05).<h4>Conclusion</h4>In critically ill patients who have large volumes of gastric aspirates indicating a failure to tolerate nasogastric feeding, a single small dose of intravenous erythromycin allows continuation of feed in the short term. | - |
dc.description.statementofresponsibility | Chapman, Marianne J.; Fraser, Robert J.; Kluger, Michal T.; Buist, Michael D.; De Nichilo, Daniela J. | - |
dc.language.iso | en | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.rights | Copyright: © 2000 Lippincott Williams & Wilkins, Inc. | - |
dc.source.uri | http://dx.doi.org/10.1097/00003246-200007000-00026 | - |
dc.subject | Humans | - |
dc.subject | Erythromycin | - |
dc.subject | Gastrointestinal Agents | - |
dc.subject | Respiration, Artificial | - |
dc.subject | Enteral Nutrition | - |
dc.subject | Critical Care | - |
dc.subject | Infusions, Intravenous | - |
dc.subject | APACHE | - |
dc.subject | Double-Blind Method | - |
dc.subject | Intubation, Gastrointestinal | - |
dc.subject | Gastric Emptying | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Erythromycin improves gastric emptying in critically ill patients intolerant of nasogastric feeding | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1097/00003246-200007000-00026 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Chapman, M. [0000-0003-0710-3283] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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