Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9411
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: The effect of acute hyperglycaemia on appetite and food intake in Type 1 diabetes mellitus
Author: Russell, A.
Horowitz, M.
Ritz, M.
MacIntosh, C.
Fraser, R.
Chapman, I.
Citation: Diabetic Medicine, 2001; 18(9):718-725
Publisher: Blackwell Science Ltd
Issue Date: 2001
ISSN: 0742-3071
1464-5491
Statement of
Responsibility: 
A. W. Russell, M. Horowitz, M. Ritz, C. MacIntosh, R. Fraser and I. M. Chapman
Abstract: AIMS: To determine the effects of acute hyperglycaemia on appetite and food intake in Type 1 diabetes mellitus. METHODS: Two separate studies, each involving eight adults with uncomplicated Type 1 diabetes, were performed: one in the fasted state (A) and the other after a nutrient preload (B). In both studies, perceptions of appetite (hunger and fullness) and food intake at a buffet meal were evaluated during euglycaemia (blood glucose, approximately 6 mmol/l) and hyperglycaemia (blood glucose, approximately 14 mmol/l). Both experiments were randomized and single-blind. In study A, appetite was assessed in the fasted state for 90 min before the buffet meal. In study B, a nutrient 'preload' of Ensure and milk containing 13C-octanoic acid was consumed 90 min before the meal. Gastric emptying of the preload was quantified with a radioisotopic breath test technique. RESULTS: There was no significant difference in plasma insulin concentrations between euglycaemia and hyperglycaemia in either study. In study A, there were no differences in hunger, fullness or energy intake between the two treatment days. In study B, subjects were slightly less hungry between the preload and buffet meal during hyperglycaemia than euglycaemia (P = 0.04), and tended to have slower gastric emptying during hyperglycaemia (emptying coefficient, 3.89 +/- 0.16 vs. 3.57 +/- 0.21; P = 0.052), but there was no difference in food intake between hyperglycaemia and euglycaemia. CONCLUSIONS: Acute hyperglycaemia suppresses hunger after a nutrient preload, but not in the fasted state, in patients with uncomplicated Type 1 diabetes. This effect is small and not associated with changes in food intake.
Keywords: appetite; blood glucose; diabetes mellitus; feeding; hyperglycaemia
Description: The definitive version is available at www.blackwell-synergy.com
RMID: 0020011063
DOI: 10.1046/j.1464-5491.2001.00545.x
Published version: http://www.blackwell-synergy.com/loi/dme
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.