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Type: Journal article
Title: Helicobacter pylori infection is not associated with delayed gastric emptying or upper gastrointestinal symptoms in diabetes mellitus
Author: Jones, K.
Wishart, J.
Berry, M.
Russo, A.
Xia, H.
Talley, N.
Horowitz, M.
Citation: Digestive Diseases and Sciences, 2002; 47(4):704-709
Publisher: Kluwer Academic/Plenum Publ
Issue Date: 2002
ISSN: 0163-2116
Statement of
Karen L. Jones, Judith M. Wishart, Melanie Berry, Antonietta Russo, Harry Hua-Xiang Xia, Nicholas J. Talley and Michael Horowitz
Abstract: This study evaluated the relationship between gastric emptying and upper gastrointestinal symptoms with H. pylori status in patients with diabetes mellitus. Sixty-three outpatients (44 type 1, 19 type 2, age 45 ± 1.5 years) underwent measurements of gastric emptying of a mixed solid and liquid meal, gastrointestinal symptoms (gastric and esophageal), glycemic control (HbAlc), and autonomic nerve function. Anti-H. pylori IgG antibodies were quantified using a validated kit. Gastric emptying of solid and/or liquid was delayed in 47 (75%) patients, and 31 (49%) had autonomic neuropathy. Fifteen (24%) of the patients were H. pylori positive. There were no differences in gastric emptying (solid retention at 100 min: 67.5 ± 5.7% vs 63.2 ± 3.6%; P = 0.63, liquid T50: 35.5 ± 2.9 min vs 42.5 ± 3.4 min; P = 0.42), upper gastrointestinal symptoms (gastric 3.9 ± 0.7 vs 4.0 ± 0.4; P = 0.94 or esophageal 1.7 ± 0.5 vs 1.3 ± 0.2; P = 0.42) or HbAlc (8.8 ± 0.4% vs 8.6 ± 0.2%; P = 0.89) between H. pylori-positive and -negative patients. We conclude that H. pylori infection is not associated with delayed gastric emptying or upper gastrointestinal symptoms in diabetes.
Keywords: Helicobacter pylori
gastric emptying
gastrointestinal symptoms
diabetes mellitus
Description: The original publication can be found at
Rights: © 2002 Plenum Publishing Corporation
DOI: 10.1023/A:1014763210890
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