Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/94526
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Type: | Conference paper |
Title: | Electroactive 3D materials for cardiac tissue engineering |
Author: | Gelmi, A. Zhang, J. Cieslar-Pobuda, A. Ljunngren, M. Los, M. Rafat, M. Jager, E. |
Citation: | Proceedings of SPIE, 2015 / Bar-Cohen, Y. (ed./s), vol.9430, pp.1-7 |
Publisher: | SPIE |
Issue Date: | 2015 |
ISBN: | 9781628415339 |
ISSN: | 0277-786X 0277-786X |
Conference Name: | Conference on Electroactive Polymer Actuators and Devices (EAPAD) (8 Mar 2015 : San Diego, CA) |
Editor: | Bar-Cohen, Y. |
Statement of Responsibility: | Amy Gelmi, Jiabin Zhang, Artur Cieslar-Pobuda, Monika K. Ljunngren, Marek Jan Los, Mehrdad Rafat, Edwin W.H. Jager |
Abstract: | By-pass surgery and heart transplantation are traditionally used to restore the heart’s functionality after a myocardial Infarction (MI or heart attack) that results in scar tissue formation and impaired cardiac function. However, both procedures are associated with serious post-surgical complications. Therefore, new strategies to help re-establish heart functionality are necessary. Tissue engineering and stem cell therapy are the promising approaches that are being explored for the treatment of MI. The stem cell niche is extremely important for the proliferation and differentiation of stem cells and tissue regeneration. For the introduction of stem cells into the host tissue an artificial carrier such as a scaffold is preferred as direct injection of stem cells has resulted in fast stem cell death. Such scaffold will provide the proper microenvironment that can be altered electronically to provide temporal stimulation to the cells. We have developed an electroactive polymer (EAP) scaffold for cardiac tissue engineering. The EAP scaffold mimics the extracellular matrix and provides a 3D microenvironment that can be easily tuned during fabrication, such as controllable fibre dimensions, alignment, and coating. In addition, the scaffold can provide electrical and electromechanical stimulation to the stem cells which are important external stimuli to stem cell differentiation. We tested the initial biocompatibility of these scaffolds using cardiac progenitor cells (CPCs), and continued onto more sensitive induced pluripotent stem cells (iPS). We present the fabrication and characterisation of these electroactive fibres as well as the response of increasingly sensitive cell types to the scaffolds. |
Rights: | © 2015 SPIE |
DOI: | 10.1117/12.2084165 |
Published version: | http://dx.doi.org/10.1117/12.2084165 |
Appears in Collections: | Aurora harvest 7 Chemical Engineering publications |
Files in This Item:
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hdl_94526.pdf | Published version | 2.1 MB | Adobe PDF | View/Open |
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