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https://hdl.handle.net/2440/95276
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Type: | Journal article |
Title: | Rhodococcus equi (Prescottella equi) vaccines; the future of vaccine development |
Author: | Giles, C. Vanniasinkam, T. Ndi, S. Barton, M. |
Citation: | Equine Veterinary Journal, 2015; 47(5):510-518 |
Publisher: | Wiley |
Issue Date: | 2015 |
ISSN: | 0425-1644 2042-3306 |
Statement of Responsibility: | C. Giles, T. Vanniasinkam, S. Ndi, and M. D. Barton |
Abstract: | For decades researchers have been targeting prevention of Rhodococcus equi (Rhodococcus hoagui/Prescottella equi) by vaccination and the horse breeding industry has supported the ongoing efforts by researchers to develop a safe and cost effective vaccine to prevent disease in foals. Traditional vaccines including live, killed and attenuated (physical and chemical) vaccines have proved to be ineffective and more modern molecular-based vaccines including the DNA plasmid, genetically attenuated and subunit vaccines have provided inadequate protection of foals. Newer, bacterial vector vaccines have recently shown promise for R. equi in the mouse model. This article describes the findings of key research in R. equi vaccine development and looks at alternative methods that may potentially be utilised. |
Keywords: | Prescottella equi Rhodococcus equi Rhodococcus hoagui foal horse respiratory disease vaccine |
Rights: | © 2014 EVJ Ltd |
DOI: | 10.1111/evj.12310 |
Published version: | http://dx.doi.org/10.1111/evj.12310 |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 3 |
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