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Type: Journal article
Title: Rhodococcus equi (Prescottella equi) vaccines; the future of vaccine development
Author: Giles, C.
Vanniasinkam, T.
Ndi, S.
Barton, M.
Citation: Equine Veterinary Journal, 2015; 47(5):510-518
Publisher: Wiley
Issue Date: 2015
ISSN: 0425-1644
Statement of
C. Giles, T. Vanniasinkam, S. Ndi, and M. D. Barton
Abstract: For decades researchers have been targeting prevention of Rhodococcus equi (Rhodococcus hoagui/Prescottella equi) by vaccination and the horse breeding industry has supported the ongoing efforts by researchers to develop a safe and cost effective vaccine to prevent disease in foals. Traditional vaccines including live, killed and attenuated (physical and chemical) vaccines have proved to be ineffective and more modern molecular-based vaccines including the DNA plasmid, genetically attenuated and subunit vaccines have provided inadequate protection of foals. Newer, bacterial vector vaccines have recently shown promise for R. equi in the mouse model. This article describes the findings of key research in R. equi vaccine development and looks at alternative methods that may potentially be utilised.
Keywords: Prescottella equi
Rhodococcus equi
Rhodococcus hoagui
respiratory disease
Rights: © 2014 EVJ Ltd
DOI: 10.1111/evj.12310
Appears in Collections:Animal and Veterinary Sciences publications
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