Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/95974
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Type: | Journal article |
Title: | Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll |
Author: | Liu, D. Shaukat, Z. Saint, R. Gregory, S. |
Citation: | Oncotarget, 2015; 6(36):38552-38565 |
Publisher: | Impact Journals |
Issue Date: | 2015 |
ISSN: | 1949-2553 1949-2553 |
Statement of Responsibility: | Dawei Liu, Zeeshan Shaukat, Robert B. Saint, and Stephen L. Gregory |
Abstract: | Chromosomal instability (CIN) is a hallmark of cancer and has been implicated in cancer initiation, progression and the development of resistance to traditional cancer therapy. Here we identify a new property of CIN cells, showing that inducing CIN in proliferating Drosophila larval tissue leads to the activation of innate immune signalling in CIN cells. Manipulation of this immune pathway strongly affects the survival of CIN cells, primarily via JNK, which responds to both Toll and TNFα/Eiger. This pathway also activates Mmp1, which recruits hemocytes to the CIN tissue to provide local amplification of the immune response that is needed for effective elimination of CIN cells. |
Keywords: | Drosophila Immune response Immunity Immunology Section TLRs TNFα chromosomal instability innate immune response |
Rights: | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.18632/oncotarget.6035 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1087308 http://purl.org/au-research/grants/nhmrc/1027878 |
Published version: | http://dx.doi.org/10.18632/oncotarget.6035 |
Appears in Collections: | Aurora harvest 7 Genetics publications |
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hdl_95974.pdf | Published version | 2.35 MB | Adobe PDF | View/Open |
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