Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/9599
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Type: Journal article
Title: Heartburn in primary care: problems below the surface
Author: Holtmann, G.
Maldonado-Lopez, E.
Haag, S.
Citation: Journal of Gastroenterology, 2004; 39(11):1027-1034
Publisher: Springer-Verlag
Issue Date: 2004
ISSN: 0944-1174
1435-5922
Statement of
Responsibility: 
Gerald Holtmann, Evelyn Maldonado-Lopez and Sebastian Haag
Abstract: Heartburn is a common physiological event often associated with an underlying occurrence of gastroesophageal reflux disease (GERD). Studies show that GERD is a highly prevalent and chronic condition that significantly impacts on the patientrsquos quality of life (QoL) and, in the long term, increases the risk for developing esophageal adenocarcinoma, more commonly referred to as Barrettrsquos esophagus. Data indicate that symptom severity is a poor predictor of either the presence of erosive mucosal lesions or the development of complications. Given that lifestyle modifications are often insufficient for long-term treatment of GERD, drugs that inhibit gastric acid production—such as the proton pump inhibitors (PPIs)—are now the most effective strategy. Although generally well tolerated, the potential of PPIs for interactions with other drugs needs to be considered. This review discusses the symptoms and risk factors associated with GERD, possible links to Helicobacter pylori infection, and effective treatment strategies within a primary care setting.
Keywords: heartburn
gastroesophageal reflux disease (GERD)
quality of life (QoL)
primary care
Rights: © Springer-Verlag 2004
DOI: 10.1007/s00535-004-1440-8
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