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https://hdl.handle.net/2440/9633
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Type: | Journal article |
Title: | Trans fatty acids in adipose tissue and the food supply are associated with myocardial infarction |
Author: | Clifton, P. Keogh, J. Noakes, M. |
Citation: | The Journal of Nutrition, 2004; 134(4):874-879 |
Publisher: | Amer Inst Nutrition |
Issue Date: | 2004 |
ISSN: | 0022-3166 1541-6100 |
Abstract: | Metabolic studies have clearly shown that trans fatty acids (TFAs) elevate LDL and lower HDL cholesterol. Epidemiologic studies showed a relation between TFA intake and the risk of myocardial infarction (MI), but studies examining adipose tissue TFAs have not uniformly confirmed this. We performed a case control study examining both adipose tissue levels and dietary intake of TFAs and first MI. Between 1995 and 1997, 209 cases of first MI completed a 300-item FFQ and 79 had an adipose tissue biopsy; 179 matched controls completed the FFQ and 167 had a biopsy. During the course of the study (mid-1996), TFAs were eliminated from margarines sold in Australia. Cases biopsied before mid-1996 had greater levels of trans 18:1(n-9) (32% P < 0.03) and trans 18:1(n-11) (23%, P < 0.001) than controls biopsied before mid-1996. After June 1996, there were no differences between cases and controls in any of the adipose tissue TFAs measured. Logistic regression showed that trans 18:1(n-11) (P = 0.03) was an independent predictor of a first MI. Cases consumed 0.5 g/d (P = 0.002) more TFAs than controls. Subjects in the highest quintile of TFA intake had an OR for first MI of 2.1 (95% CI, 1.1-4.3), which was not independent of saturated fat intake. Apparent TFA intake from margarine was related to adipose tissue 18:1t[(n-9) and (n-10)] in 1995 (r = 0.66, 0.66, respectively). We conclude that TFAs in adipose tissue are associated with an increased risk of coronary artery disease and rapidly disappear from adipose tissue when not included in margarines. |
Keywords: | Adipose Tissue Humans Coronary Disease Myocardial Infarction Dietary Fats Margarine Trans Fatty Acids Biopsy Logistic Models Odds Ratio Risk Factors Case-Control Studies Aged Middle Aged Female Male Cholesterol, LDL Cholesterol, HDL |
DOI: | 10.1093/jn/134.4.874 |
Published version: | http://dx.doi.org/10.1093/jn/134.4.874 |
Appears in Collections: | Aurora harvest Medicine publications |
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