Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/96352
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Smith, E. | - |
dc.contributor.author | Palethorpe, H. | - |
dc.contributor.author | Ruszkiewicz, A. | - |
dc.contributor.author | Edwards, S. | - |
dc.contributor.author | Leach, D. | - |
dc.contributor.author | Underwood, T. | - |
dc.contributor.author | Need, E. | - |
dc.contributor.author | Drew, P. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Digestive Diseases and Sciences, 2016; 61(2):433-443 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.issn | 1573-2568 | - |
dc.identifier.uri | http://hdl.handle.net/2440/96352 | - |
dc.description.abstract | BACKGROUND: Esophageal adenocarcinoma is a male-dominant disease, but the role of androgens is unclear. AIMS: To examine the expression and clinical correlates of the androgen receptor (AR) and the androgen-responsive gene FK506-binding protein 5 (FKBP5) in esophageal adenocarcinoma. METHODS: Expression of AR and FKBP5 was determined by immunohistochemistry. The effect of the AR ligand 5α-dihydrotestosterone (DHT) on the expression of a panel of androgen-responsive genes was measured in AR-positive and AR-negative esophageal adenocarcinoma cell lines. Correlations in expression between androgen-responsive genes were analyzed in an independent cohort of esophageal adenocarcinoma tissues. RESULTS: There was AR staining in 75 of 77 cases (97 %), and FKBP5 staining in 49 (64 %), all of which had nuclear AR. Nuclear AR with FKBP5 expression was associated with decreased median survival (451 vs. 2800 days) and was an independent prognostic indicator (HR 2.894, 95 % CI 1.396-6.002, p = 0.0043) in multivariable Cox proportional hazards models. DHT induced a significant increase in expression of the androgen-responsive genes FKBP5, HMOX1, FBXO32, VEGFA, WNT5A, and KLK3 only in AR-positive cells in vitro. Significant correlations in expression were observed between these androgen-responsive genes in an independent cohort of esophageal adenocarcinoma tissues. CONCLUSION: Nuclear AR and expression of FKBP5 is associated with decreased survival in esophageal adenocarcinoma. | - |
dc.description.statementofresponsibility | Eric Smith, Helen M. Palethorpe, Andrew R. Ruszkiewicz, Suzanne Edwards, Damien A. Leach, Tim J. Underwood, Eleanor F. Need, Paul A. Drew | - |
dc.language.iso | en | - |
dc.publisher | Springer | - |
dc.rights | © Springer Science+Business Media New York 2015 | - |
dc.source.uri | http://dx.doi.org/10.1007/s10620-015-3909-0 | - |
dc.subject | Adenocarcinoma of the esophagus | - |
dc.subject | Androgen receptors | - |
dc.subject | FK506-binding protein 5 | - |
dc.subject | Prognosis | - |
dc.subject | Steroids | - |
dc.title | Androgen receptor and androgen-responsive gene FKBP5 are independent prognostic indicators for esophageal adenocarcinoma | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s10620-015-3909-0 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Smith, E. [0000-0003-2958-3492] | - |
dc.identifier.orcid | Palethorpe, H. [0000-0003-3803-5113] | - |
dc.identifier.orcid | Ruszkiewicz, A. [0000-0001-9052-4948] | - |
dc.identifier.orcid | Edwards, S. [0000-0003-2074-1685] | - |
dc.identifier.orcid | Drew, P. [0000-0001-5661-4771] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_96352.pdf | Accepted Version | 381.29 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.