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Type: Journal article
Title: Coronary flow velocity reserve does not correlate with TIMI frame count in patients undergoing non-emergency percutaneous coronary intervention
Author: Chugh, S.
Koppel, J.
Scott, M.
Shewchuk, L.
Goodhart, D.
Bonan, R.
Tardif, J.
Worthley, S.
DiMario, C.
Curtis, M.
Meredith, I.
Anderson, T.
Citation: Journal of the American College of Cardiology, 2004; 44(4):778-782
Publisher: Elsevier Science Inc
Issue Date: 2004
ISSN: 0735-1097
Statement of
Sanjay K. Chugh, Jennifer Koppel, Mark Scott, Lana Shewchuk, David Goodhart, Raoul Bonan, Jean-Claude Tardif, Stephen G. Worthley, Carlo DiMario, Michael J. Curtis, Ian T. Meredith, Todd J. Anderson
Abstract: Objectives The purpose of this research was to compare the Thrombolysis In Myocardial Infarction (TIMI) frame count (CTFC) with coronary flow velocity reserve (CFVR) in patients undergoing percutaneous coronary intervention (PCI). Background The relationship between CTFC and CFVR has not been adequately assessed in patients with coronary artery disease. Methods We studied 62 patients who underwent successful non-emergent PCI. All patients had Doppler evaluation of CFVR, CTFC, and quantitative coronary angiography. In an additional 17 patients, a frame count reserve was calculated as baseline CTFC/CTFC at peak hyperemia, induced by intracoronary adenosine after PCI. Results The CTFC decreased from 27 ± 13 to 18 ± 8, and CFVR increased from 1.5 ± 0.4 to 2.6 ± 0.7 (both p < 0.0001). The pre-PCI CTFC and the CFVR were closely related to minimal lumen diameter (p < 0.0001). After PCI, there was no correlation between CFVR and CTFC. In addition, no relationship was observed between CFVR and the frame count reserve. Conclusions There was no significant correlation between CFVR and CTFC in patients undergoing coronary intervention. The relative utility of these measures in predicting outcomes in this setting requires further evaluation, but CTFC (or frame count reserve) does not appear to be an adequate surrogate measure of Doppler-derived CFVR.
Keywords: Coronary Vessels
Myocardial Infarction
Blood Flow Velocity
Collateral Circulation
Coronary Circulation
Middle Aged
Angioplasty, Balloon, Coronary
Description: © 2004 American College of Cardiology Foundation. Published by Elsevier Inc.
DOI: 10.1016/j.jacc.2004.05.048
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