Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9655
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Type: Journal article
Title: Effects of aging on the opioid modulation of feeding in humans
Author: MacIntosh, C.
Sheehan, J.
Davani, N.
Morley, J.
Horowitz, M.
Chapman, I.
Citation: Journal of the American Geriatrics Society, 2001; 49(11):1518-1524
Publisher: Blackwell Science Inc.
Issue Date: 2001
ISSN: 0002-8614
1532-5415
Statement of
Responsibility: 
Caroline G. MacIntosh, Jessica Sheehan, Nusha Davani, John E. Morley, Michael Horowitz, Ian M. Chapman
Abstract: OBJECTIVES: To determine whether aging is associated with a reduction in the opioid modulation of feeding, which may be important in the pathogenesis of the "anorexia of aging." DESIGN: Three studies on separate days, in randomized order and double-blind fashion. SETTING: Clinical Human Research Laboratory, Department of Medicine, RAH, Adelaide, Australia. PARTICIPANTS: Twelve older (5 male/7 female) (age 65-84) and 12 young (5 male/7 female) (age 20-26) healthy subjects. INTERVENTION: Subjects received in double-blinded random order, intravenous bolus (10 minutes) and then continuous (140 minutes) infusions of saline (control), naloxone low dose (LD) (bolus 27 microg/kg; continuous 50 microg/kg/hr), or naloxone high dose (HD) (bolus 54.5 microg/kg; continuous 100 microg/kg/hr). MEASUREMENTS: After 120 minutes, subjects were offered a buffet meal, and their energy intake was quantified. Hunger, fullness, nausea, and drowsiness were assessed using visual analogue scales. RESULTS: The naloxone LD and HD infusions had no significant effect on ratings of hunger, fullness, or nausea, but increased drowsiness (P < .01) compared with the control infusion in both age groups. Older subjects ate less (P < .001) at the buffet meal than young subjects during all three infusions. Naloxone infusions reduced energy intake compared with control (P < .001), LD by 13.2 +/- 5.0% and HD by 10.7 +/- 5.0%, with no difference between the doses (P = .71). Overall, naloxone suppressed energy intake in both young and older subjects (P < .01). This suppression was slightly, but not significantly, greater in young than in older subjects (mean of LD and HD 16.4 +/- 4.9% vs 7.5 +/- 4.9%, P = .42), because of a trend to reduced suppression in older women. CONCLUSIONS: We conclude that healthy older adults retain their sensitivity to the suppressive effects of naloxone on food intake. Possible gender differences in this sensitivity warrant further investigation. A decline in opioid activity is unlikely to contribute substantially to the physiological anorexia of aging observed in older people.
Keywords: opioids; naloxone; appetite; food intake; aging
Description: The definitive version is available at www.blackwell-synergy.com
RMID: 0020011085
DOI: 10.1046/j.1532-5415.2001.4911246.x
Appears in Collections:Medicine publications

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