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https://hdl.handle.net/2440/96783
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dc.contributor.author | Collins, M.G. | - |
dc.contributor.author | Rogers, N.M. | - |
dc.contributor.author | Jesudason, S. | - |
dc.contributor.author | Kireta, S. | - |
dc.contributor.author | Brealey, J. | - |
dc.contributor.author | Coates, P.T. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Medical Primatology, 2014; 43(6):477-487 | - |
dc.identifier.issn | 0047-2565 | - |
dc.identifier.issn | 1600-0684 | - |
dc.identifier.uri | http://hdl.handle.net/2440/96783 | - |
dc.description | Article first published online: 30 JUN 2014 | - |
dc.description.abstract | BACKGROUND: Common marmosets are known to develop an IgM glomerulopathy, which has been linked with 'wasting marmoset' syndrome. This study investigated renal pathology in a colony of marmosets, with and without weight loss. METHODS: Renal histology, immunofluorescence, and electron microscopy were performed on marmosets euthanized for research or for weight loss. Serum and urine biochemistry were measured during life and at euthanasia. RESULTS: Histology from 25 adult marmosets (19 research and 6 weight loss) showed mesangial expansion in the majority of glomeruli. Mesangial changes correlated with electron-dense deposits and IgM deposition by immunofluorescence; negligible other pathology was seen. Glomerular basement membrane thickness appeared increased compared to reported human measurements. Low-grade proteinuria was present in all animals, but did not progress. Renal function was normal in all animals. CONCLUSIONS: Marmosets develop a glomerulopathy characterized by mesangial expansion, IgM deposition, and proteinuria. This is a benign occurrence and not specifically associated with weight loss. | - |
dc.description.statementofresponsibility | Michael G. Collins, Natasha M. Rogers, Shilpanjali Jesudason, Svjetlana Kireta, John Brealey and Patrick Toby Coates | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd | - |
dc.source.uri | http://dx.doi.org/10.1111/jmp.12134 | - |
dc.subject | Callitrichidae; glomerular disease; immune complex deposition; mesangium; non-human primates; proteinuria | - |
dc.title | Spontaneous glomerular mesangial lesions in common marmoset monkeys (Callithrix jacchus): a benign non-progressive glomerulopathy | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/jmp.12134 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/399374 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/563800 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Collins, M.G. [0000-0003-2169-9087] | - |
dc.identifier.orcid | Jesudason, S. [0000-0001-9695-0761] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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