Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/96783
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dc.contributor.authorCollins, M.en
dc.contributor.authorRogers, N.en
dc.contributor.authorJesudason, S.en
dc.contributor.authorKireta, S.en
dc.contributor.authorBrealey, J.en
dc.contributor.authorCoates, P.en
dc.date.issued2014en
dc.identifier.citationJournal of Medical Primatology, 2014; 43(6):477-487en
dc.identifier.issn0047-2565en
dc.identifier.issn1600-0684en
dc.identifier.urihttp://hdl.handle.net/2440/96783-
dc.descriptionArticle first published online: 30 JUN 2014en
dc.description.abstractBACKGROUND: Common marmosets are known to develop an IgM glomerulopathy, which has been linked with 'wasting marmoset' syndrome. This study investigated renal pathology in a colony of marmosets, with and without weight loss. METHODS: Renal histology, immunofluorescence, and electron microscopy were performed on marmosets euthanized for research or for weight loss. Serum and urine biochemistry were measured during life and at euthanasia. RESULTS: Histology from 25 adult marmosets (19 research and 6 weight loss) showed mesangial expansion in the majority of glomeruli. Mesangial changes correlated with electron-dense deposits and IgM deposition by immunofluorescence; negligible other pathology was seen. Glomerular basement membrane thickness appeared increased compared to reported human measurements. Low-grade proteinuria was present in all animals, but did not progress. Renal function was normal in all animals. CONCLUSIONS: Marmosets develop a glomerulopathy characterized by mesangial expansion, IgM deposition, and proteinuria. This is a benign occurrence and not specifically associated with weight loss.en
dc.description.statementofresponsibilityMichael G. Collins, Natasha M. Rogers, Shilpanjali Jesudason, Svjetlana Kireta, John Brealey and Patrick Toby Coatesen
dc.language.isoenen
dc.publisherWileyen
dc.rights© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltden
dc.subjectCallitrichidae; glomerular disease; immune complex deposition; mesangium; non-human primates; proteinuriaen
dc.titleSpontaneous glomerular mesangial lesions in common marmoset monkeys (Callithrix jacchus): a benign non-progressive glomerulopathyen
dc.typeJournal articleen
dc.identifier.rmid0030017732en
dc.identifier.doi10.1111/jmp.12134en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/399374en
dc.identifier.pubid113732-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS03en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCollins, M. [0000-0003-2169-9087]en
dc.identifier.orcidJesudason, S. [0000-0001-9695-0761]en
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