Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9710
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Type: Journal article
Title: Antropyloroduodenal, cholecystokinin and feeding responses to pulsatile and non-pulsatile intraduodenal lipid infusion
Author: Yandell, R.
Su, Y.
Fraser, R.
Wittert, G.
Horowitz, M.
Malbert, C.
Shulkes, A.
Volombello, T.
Chapman, I.
Citation: Neurogastroenterology and Motility, 2002; 14(1):25-33
Publisher: Blackwell Science Ltd
Issue Date: 2002
ISSN: 1350-1925
1365-2982
Statement of
Responsibility: 
R. Vozzo, Y-C. Su, R. J. Fraser, G. A. Wittert, M. Horowitz, C. H. Malbert,  A. Shulkes, T. Volombello & I. M. Chapman
Abstract: The contribution of the pulsatile nature of gastric emptying to small intestinal feedback mechanisms modulating antropyloroduodenal motility and appetite is unknown. On separate days, eight healthy male volunteers (18-34 years) received randomized, single-blind, intraduodenal (ID) infusions of 10% Intralipid (2 kcal min(-1)), either continuously [CID], or in a pulsatile manner [PID] (5 s on/15 s off) and 0.9% saline (control) administered continuously, each at a rate of 1.8 mL min(-1) for 3 h. During each infusion, subjective ratings of appetite were assessed and antropyloroduodenal pressures recorded with a 16-lumen manometric assembly incorporating a pyloric sleeve sensor. Plasma cholecystokinin was measured from blood collected at regular intervals throughout the infusion. At the end of each infusion the manometric assembly was removed, subjects were offered a buffet meal and the energy and macronutrient content of the meal was measured. Both ID lipid infusions stimulated isolated pyloric pressure waves (IPPWs) (P < 0.001) and basal pyloric pressure (P < 0.01) and suppressed antral (P < 0.05) and duodenal (P < 0.05) pressure waves when compared to controls; there was no difference in the effects of CID and PID lipid on antropyloroduodenal pressures. Infusions of lipid significantly increased plasma CCK concentrations (P < 0.05) compared with saline, but concentrations were not different between the two modes of lipid delivery (P > 0.05, CID vs. PID). Both intraduodenal lipid infusions decreased hunger (P < 0.05), increased fullness (P < 0.05) and reduced energy intake (P < 0.05) when compared with controls; again there was no difference between CID and PID lipid. We conclude that at the infusion rate of similar 2 kcal min(-1), the acute effects of intraduodenal lipid on antropyloroduodenal pressures, plasma CCK concentration and appetite are not modified by a pulsatile mode of lipid delivery into the duodenum.
Keywords: motility; pylorus; sensation
Description: The definitive version is available at www.blackwell-synergy.com
RMID: 0020020103
DOI: 10.1046/j.1365-2982.2002.00299.x
Appears in Collections:Medicine publications

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