Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/97563
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Type: Journal article
Title: When two obese parents are worse than one! Impacts on embryo and fetal development
Author: McPherson, N.
Bell, V.
Zander-Fox, D.
Fullston, T.
Wu, L.
Robker, R.
Lane, M.
Citation: American Journal of Physiology: Endocrinology and Metabolism, 2015; 309(6):E568-E581
Publisher: American Physiological Society
Issue Date: 2015
ISSN: 0193-1849
1522-1555
Statement of
Responsibility: 
N. O. McPherson, V. G. Bell, D. L. Zander-Fox, T. Fullston, L. L. Wu, R. L. Robker, M. Lane
Abstract: The prevalence of overweight and obesity in reproductively aged adults is increasing worldwide. While the effects of either paternal or maternal obesity on gamete health and subsequent fertility and pregnancy have been reported independently, the combination of having both parents overweight/obese on fecundity and offspring health has received minimal attention. Using a 2x2 study design in rodents we established the relative contributions of paternal and maternal obesity on fetal and embryo development and whether combined paternal and maternal obesity had an additive effect. Here we show that parental obesity reduces fetal and placental weights without altering pregnancy establishment and is not dependent on an in utero exposure to a high fat diet. Interestingly combined parental obesity seemed to accumulate of both the negative influences paternal and maternal obesity had alone on embryo and fetal health rather than an amplification, manifested as reduced embryo developmental competency, reduced blastocyst cell numbers, impaired mitochondrial function, alterations to active and repressive embryonic chromatin marks, resulting in aberrant placental gene expression and reduced fetal liver mtDNA copy numbers. Further understanding both the maternal cytoplasmic and paternal genetic interactions during this early developmental time frame will be vital for understanding how developmental programming is regulated and for the proposition of interventions to mitigate their effects.
Keywords: blastocyst
fertiity
obesity
oocyte
sperm
Rights: © 2015 the American Physiological Society
DOI: 10.1152/ajpendo.00230.2015
Appears in Collections:Aurora harvest 7
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