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https://hdl.handle.net/2440/9770
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Type: | Journal article |
Title: | Molecular monitoring of chronic myeloid leukemia |
Author: | Hughes, T. Branford, S. |
Citation: | Seminars in Hematology, 2003; 40(2):62-68 |
Publisher: | W B Saunders Co |
Issue Date: | 2003 |
ISSN: | 0037-1963 1532-8686 |
Abstract: | The tyrosine kinase inhibitor imatinib mesylate (Gleevec) (formerly STI571) has proven to be an effective and safe new therapy for patients with chronic myeloid leukemia (CML). It has induced short-term hematologic control in many patients with advanced-phase CML, with some patients achieving durable responses. In chronic-phase patients it induces significantly better cytogenetic responses and lower progression rates than interferon-alpha. However, relapse is a significant problem, especially for advanced-phase patients, and imatinib alone appears unlikely to be curative in any patient group. Real-time quantitative polymerase chain reaction (Q-PCR) provides an accurate, sensitive, and noninvasive measure of residual leukemia in patients on imatinib. Levels of BCR-ABL in the blood correlate strongly with the bone marrow cytogenetic results and early measurement can predict subsequent cytogenetic response. Complete molecular responses (no BCR-ABL detected by real-time Q-PCR) are rarely achieved. Sequential real-time Q-PCR studies should facilitate rational patient management and allow comparison of different imatinib-based treatment strategies. It may be possible to define levels of molecular response that predict long-term disease control. In addition, by defining patterns of response, an early indication of imatinib resistance may be detected. |
Keywords: | Humans Benzamides Piperazines Pyrimidines Fusion Proteins, bcr-abl Prognosis Molecular Diagnostic Techniques Polymerase Chain Reaction Leukemia, Myelogenous, Chronic, BCR-ABL Positive Imatinib Mesylate |
DOI: | 10.1053/shem.2003.50044 |
Published version: | http://dx.doi.org/10.1053/shem.2003.50044 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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