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Type: Journal article
Title: Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice
Author: Chen, J.
Zhang, X.D.
Proud, C.
Citation: Science Signaling, 2015; 8(392):pe1-1-pe1-3
Publisher: American Association for the Advancement of Science
Issue Date: 2015
ISSN: 1945-0877
Statement of
Jiezhong Chen, Xu Dong Zhang, Christopher Proud
Abstract: Double knockout of PTEN and LKB1-genes encoding phosphatase and tensin homolog and liver kinase B1, respectively-leads to the spontaneous development of cancer in mice. PTEN converts phosphatidylinositol (3,4,5)-trisphosphate (PIP3) to phosphatidylinositol (4,5)-bisphosphate (PIP2), whereas LKB1 activates the 5' adenosine monophosphate-activated protein kinase (AMPK). The kinase AKT and the kinase complex mTORC1 may play key roles in carcinogenesis and are components of signaling pathways that also contain PTEN and LKB1. We propose that via activation of AKT and mTORC1, the double knockout of PTEN and LKB1 contributes to distinct cell-specific aspects of tumor development and progression. Whereas mTORC1 promotes cancer initiation and progression through cell growth, survival, and proliferation, independent induction of the immune inhibitory molecule PD-L1 by activated AKT enables the tumors to evade immunosurveillance.
Keywords: Animals
Mice, Knockout
Multiprotein Complexes
Protein-Serine-Threonine Kinases
Signal Transduction
Cell Proliferation
Cell Survival
Tumor Escape
Proto-Oncogene Proteins c-akt
PTEN Phosphohydrolase
TOR Serine-Threonine Kinases
Mechanistic Target of Rapamycin Complex 1
Rights: Copyright 2016 by the American Association for the Advancement of Science; all rights reserved.
DOI: 10.1126/scisignal.aac8321
Grant ID:
Appears in Collections:Aurora harvest 3
Molecular and Biomedical Science publications

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