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Type: Journal article
Title: Cohort profile: the 'Children of the 90s' - the index offspring of the Avon Longitudinal Study of Parents and Children
Author: Boyd, A.
Golding, J.
Macleod, J.
Lawlor, D.
Fraser, A.
Henderson, J.
Molloy, L.
Ness, A.
Ring, S.
Smith, G.
Citation: International Journal of Epidemiology, 2013; 42(1):111-127
Publisher: Oxford University Press
Issue Date: 2013
ISSN: 0300-5771
Statement of
Andy Boyd, Jean Golding, John Macleod, Debbie A Lawlor, Abigail Fraser, John Henderson, Lynn Molloy, Andy Ness, Susan Ring and George Davey Smith
Abstract: The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational prospective observational study investigating influences on health and development across the life course. It considers multiple genetic, epigenetic, biological, psychological, social and other environmental exposures in relation to a similarly diverse range of health, social and developmental outcomes. Recruitment sought to enroll pregnant women in the Bristol area of the UK during 1990-92; this was extended to include additional children eligible using the original enrollment definition up to the age of 18 years. The children from 14541 pregnancies were recruited in 1990-92, increasing to 15247 pregnancies by the age of 18 years. This cohort profile describes the index children of these pregnancies. Follow-up includes 59 questionnaires (4 weeks-18 years of age) and 9 clinical assessment visits (7-17 years of age). The resource comprises a wide range of phenotypic and environmental measures in addition to biological samples, genetic (DNA on 11343 children, genome-wide data on 8365 children, complete genome sequencing on 2000 children) and epigenetic (methylation sampling on 1000 children) information and linkage to health and administrative records. Data access is described in this article and is currently set up as a supported access resource. To date, over 700 peer-reviewed articles have been published using ALSPAC data.
Keywords: Humans
Rights: © The Author 2012; all rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Published by Oxford University Press on behalf of the International Epidemiological Association
DOI: 10.1093/ije/dys064
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