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Type: Journal article
Title: Avian influenza virus and DIVA strategies
Author: Hasan, N.
Ignjatovic, J.
Peaston, A.
Hemmatzadeh, F.
Citation: Viral Immunology, 2016; 29(4):198-211
Publisher: Mary Ann Liebert
Issue Date: 2016
ISSN: 0882-8245
Statement of
Noor Haliza Hasan, Jagoda Ignjatovic, Anne Peaston, and Farhid Hemmatzadeh
Abstract: Vaccination is becoming a more acceptable option in the effort to eradicate avian influenza viruses (AIV) from commercial poultry, especially in countries where AIV is endemic. The main concern surrounding this option has been the inability of the conventional serological tests to differentiate antibodies produced due to vacci- nation from antibodies produced in response to virus infection. In attempts to address this issue, at least six strategies have been formulated, aiming to differentiate infected from vaccinated animals (DIVA), namely (i) sentinel birds, (ii) subunit vaccine, (iii) heterologous neuraminidase (NA), (iv) nonstructural 1 (NS1) protein, (v) matrix 2 ectodomain (M2e) protein, and (vi) haemagglutinin subunit 2 (HA2) glycoprotein. This short review briefly discusses the strengths and limitations of these DIVA strategies, together with the feasibility and practicality of the options as a part of the surveillance program directed toward the eventual eradication of AIV from poultry in countries where highly pathogenic avian influenza is endemic.
Keywords: Animals
Influenza A virus
Viral Nonstructural Proteins
Hemagglutinin Glycoproteins, Influenza Virus
Influenza Vaccines
Antibodies, Viral
Serologic Tests
Endemic Diseases
Influenza in Birds
Epidemiological Monitoring
Sentinel Species
Rights: © Mary Ann Liebert, Inc.
DOI: 10.1089/vim.2015.0127
Appears in Collections:Animal and Veterinary Sciences publications
Aurora harvest 3

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