Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Avian influenza virus and DIVA strategies|
|Citation:||Viral Immunology, 2016; 29(4):198-211|
|Publisher:||Mary Ann Liebert|
|Noor Haliza Hasan, Jagoda Ignjatovic, Anne Peaston, and Farhid Hemmatzadeh|
|Abstract:||Vaccination is becoming a more acceptable option in the effort to eradicate avian influenza viruses (AIV) from commercial poultry, especially in countries where AIV is endemic. The main concern surrounding this option has been the inability of the conventional serological tests to differentiate antibodies produced due to vacci- nation from antibodies produced in response to virus infection. In attempts to address this issue, at least six strategies have been formulated, aiming to differentiate infected from vaccinated animals (DIVA), namely (i) sentinel birds, (ii) subunit vaccine, (iii) heterologous neuraminidase (NA), (iv) nonstructural 1 (NS1) protein, (v) matrix 2 ectodomain (M2e) protein, and (vi) haemagglutinin subunit 2 (HA2) glycoprotein. This short review briefly discusses the strengths and limitations of these DIVA strategies, together with the feasibility and practicality of the options as a part of the surveillance program directed toward the eventual eradication of AIV from poultry in countries where highly pathogenic avian influenza is endemic.|
|Keywords:||Animals; Chickens; Influenza A virus; Neuraminidase; Viral Nonstructural Proteins; Hemagglutinin Glycoproteins, Influenza Virus; Influenza Vaccines; Antibodies, Viral; Serologic Tests; Vaccination; Endemic Diseases; Influenza in Birds; Epidemiological Monitoring; Sentinel Species|
|Rights:||© Mary Ann Liebert, Inc.|
|Appears in Collections:||Animal and Veterinary Sciences publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.