Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/99877
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dc.contributor.authorMarathe, C.en
dc.contributor.authorFeinle-Bisset, C.en
dc.contributor.authorPilichiewicz, A.en
dc.contributor.authorLange, K.en
dc.contributor.authorJones, K.en
dc.contributor.authorRayner, C.en
dc.contributor.authorKahn, S.en
dc.contributor.authorHorowitz, M.en
dc.date.issued2015en
dc.identifier.citationDiabetic Medicine, 2015; 32(11):1500-1503en
dc.identifier.issn0742-3071en
dc.identifier.issn1464-5491en
dc.identifier.urihttp://hdl.handle.net/2440/99877-
dc.description.abstractAim: In healthy subjects, the oral disposition index (ratio of insulin response to insulin sensitivity) is predictive of the development of Type 2 diabetes. Gastric emptying, which exhibits a substantial interindividual variation, is a major determinant of postprandial glycaemia in health and diabetes. We sought to determine whether the rate of intraduodenal glucose delivery affects the disposition index in people without diabetes. Methods: Nineteen Caucasian males received glucose infusions via an intraduodenal catheter at either 2 kcal/min (ID2) or 4 kcal/min (ID4) for 120 min, on two separate days with measurements of blood glucose (G) and plasma insulin (I) at frequent intervals. The insulin response was estimated by the ratio of the change in insulin to that of change in glucose at 30 min (∆I0–30/∆G0–30) and 60 min (∆I0–60/∆G0–60). Insulin sensitivity was estimated as 1/fasting insulin. The oral disposition index (DI) was calculated as ∆I0–30/∆G0–30 × 1/fasting insulin and ∆I0–60/∆G0–60 × 1/fasting insulin. Results: The overall glycaemic response was comparable on both days, but the insulin response was much greater at ID4 when calculated at either 30 or 60 min (P < 0.05). DI was also greater (P < 0.05) in response to ID4 than ID2. Conclusions: The rate of duodenal glucose delivery has a major impact on insulin release and, thereby, DI. This suggests that the rate of gastric emptying, which determines duodenal glucose delivery, is a determinant of DI.en
dc.description.statementofresponsibilityC. S. Marathe, C. Feinle-Bisset, A. Pilichiewicz, K. Lange, K. L. Jones, C. K. Rayner, S. E. Kahn and M. Horowitzen
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.rights© 2015 The Authors. Diabetic Medicine © 2015 Diabetes UKen
dc.subjectIntestinal Mucosa; Duodenum; Humans; Insulin Resistance; Insulin; Dietary Carbohydrates; Glucose; Blood Glucose; Intubation, Gastrointestinal; Gastric Emptying; Intestinal Absorption; Kinetics; Algorithms; Adult; Male; Insulin-Secreting Cells; Glycemic Load; Insulin Secretionen
dc.titleThe duodenal glucose load impacts the oral disposition index in healthy subjectsen
dc.typeJournal articleen
dc.identifier.rmid0030029220en
dc.identifier.doi10.1111/dme.12802en
dc.identifier.pubid186541-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
Appears in Collections:Medicine publications

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