Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/99980
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Type: | Journal article |
Title: | Inflammation in acute CNS injury: a focus on the role of substance P |
Author: | Corrigan, F. Vink, R. Turner, R.J. |
Citation: | British Journal of Pharmacology, 2016; 173(4):703-715 |
Publisher: | Wiley |
Issue Date: | 2016 |
ISSN: | 0007-1188 1476-5381 |
Statement of Responsibility: | F Corrigan, R Vink, and R J Turner |
Abstract: | Recently, a number of reports have shown that neurogenic inflammation may play a role in the secondary injury response following acute injury to the CNS, including traumatic brain injury (TBI) and stroke. In particular substance P (SP) release appears to be critically involved. Specifically, the expression of the neuropeptide SP is increased in acute CNS injury, with the magnitude of SP release being related to both the frequency and magnitude of the insult. SP release is associated with an increase in blood-brain barrier permeability and the development of vasogenic oedema as well as neuronal injury and worse functional outcome. Moreover, inhibiting the actions of SP through use of a NK1 receptor antagonist is highly beneficial in both focal and diffuse models of TBI, as well as in ischaemic stroke, with a therapeutic window of up to 12 h. We propose that NK1 receptor antagonists represent a novel therapeutic option for treatment of neurogenic inflammation following acute CNS injury. |
Keywords: | Central Nervous System Animals Humans Inflammation Substance P Neurokinin-1 Receptor Antagonists |
Rights: | © 2015 The British Pharmacological Society |
DOI: | 10.1111/bph.13155 |
Published version: | http://dx.doi.org/10.1111/bph.13155 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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hdl_99980.pdf | Accepted version | 428.41 kB | Adobe PDF | View/Open |
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