Clinical observations of biofouling on PEO coated silicone hydrogel contact lenses
Date
2010
Authors
Thissen, H.
Genenbach, T.
du, T.R.
Sweeney, D.F.
Kingshott, P.
Griesser, H.J.
Meagher, L.
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Journal article
Citation
Biomaterials, 2010; 31(21):5510-5519
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Abstract
Silicone hydrogel contact lenses, which have been a major advance in the field of vision correction,require surface modification or coatings for comfort and biocompatibility. While current coatings show adequate clinical performance, advanced coatings may improve the biocompatibility of contact lenses further by reducing biofouling and related adverse clinical events. Here, we have produced coatings onLotrafilcon A contact lenses by deposition of a thin film of allylamine plasma polymer (ALAPP) asa reactive interlayer for the high density grafting of poly(ethylene oxide) dialdehyde (PEO(ALD)2), whichhad previously shown complete resistance to protein adsorption in vitro. The performance of thesecontact lenses was evaluated in a controlled clinical study over 6 h using Focus Night and Day (also known as Air Optix Night & Day) contact lenses as control lenses. Surface modified lenses werecharacterised by X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) before andafter wear. Clinical data showed a high level of biocompatibility of the PEO coated lenses equivalent tocontrol lenses. Surface analysis of worn contact lenses demonstrated that the high density PEO coating iseffective in reducing biofouling in vivo compared to control lenses, however small amounts of proteindeposits were still detected on all worn contact lenses. This study highlights that elimination ofbiofouling in vivo can be much more demanding than in vitro and discusses issues that are important forthe analysis of worn contact lenses as well as the design of improved contact lenses
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Crown Copyright 2010 Elsevier