Antibody response to pneumococcal vaccination in children younger than five years of age

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dc.contributor.authorDouglas, R.M.
dc.contributor.authorPaton, J.C.
dc.contributor.authorDuncan, S.J.
dc.contributor.authorHansman, D.J.
dc.date.issued1983
dc.description.abstractSera were analyzed by radioimmunoassay for type-specific pneumococcal antibody in 249 children aged six to 54 months, who were participating in a controlled trial of a 14-valent pneumococcal vaccine. Levels of serum antibody to all serotypes increased after immunization in all age groups tested. For all serotypes, the antibody response increased progressively with age whether response was viewed as antibody doubling, relative increase in geometric mean, or final antibody level. Responses were poor up to the age of five years for the important pediatric serotypes 6A, 14, 19F, and 23F. Seventeen children under the age of two years at the time of primary immunization received booster doses of vaccine six months later. There was no significant increase in antibody to any serotype, and the geometric mean antibody levels fell for most types. Immune response to the pediatric serotypes was poor until the age of 4.5 years.
dc.description.statementofresponsibilityR. M. Douglas, J. C. Paton, S. J. Duncan and D. J. Hansman
dc.identifier.citationJournal of Infectious Diseases, 1983; 148(1):131-137
dc.identifier.doi10.1093/infdis/148.1.131
dc.identifier.issn0022-1899
dc.identifier.issn1537-6613
dc.identifier.orcidPaton, J.C. [0000-0001-9807-5278]
dc.identifier.urihttp://hdl.handle.net/2440/85736
dc.language.isoen
dc.publisherOxford University Press
dc.rights© 1983 by The University of Chicago
dc.source.urihttps://doi.org/10.1093/infdis/148.1.131
dc.subjectHumans
dc.subjectStreptococcus pneumoniae
dc.subjectPneumococcal Infections
dc.subjectBacterial Vaccines
dc.subjectPneumococcal Vaccines
dc.subjectAntibodies, Bacterial
dc.subjectPlacebos
dc.subjectImmunization, Secondary
dc.subjectDose-Response Relationship, Immunologic
dc.subjectAging
dc.subjectTime Factors
dc.subjectChild, Preschool
dc.subjectInfant
dc.titleAntibody response to pneumococcal vaccination in children younger than five years of age
dc.typeJournal article
pubs.publication-statusPublished

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