Cross-sectional and longitudinal determinants of serum sex hormone binding globulin (SHBG) in a cohort of community-dwelling men

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dc.contributor.authorGyawali, P.
dc.contributor.authorMartin, S.A.
dc.contributor.authorHeilbronn, L.K.
dc.contributor.authorVincent, A.D.
dc.contributor.authorJenkins, A.J.
dc.contributor.authorJanuszewski, A.S.
dc.contributor.authorTaylor, A.W.
dc.contributor.authorAdams, R.J.T.
dc.contributor.authorO Loughlin, P.D.
dc.contributor.authorWittert, G.A.
dc.contributor.editorBonnet, F.
dc.date.issued2018
dc.description.abstractDespite its widespread clinical use, there is little data available from population-based studies on the determinants of serum sex hormone binding globulin (SHBG). We aimed to examine multifactorial determinants of circulating SHBG levels in community-dwelling men. Study participants comprised randomly selected 35±80 y.o. men (n = 2563) prospectively-followed for 5 years (n = 2038) in the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study. After excluding men with illness or medications known to affect SHBG (n = 172), data from 1786 men were available at baseline, and 1476 at follow-up. The relationship between baseline body composition (DXA), serum glucose, insulin, triglycerides, thyroxine (fT4), sex steroids (total testosterone (TT), oestradiol (E2)), and pro-inflammatory cytokines and serum SHBG level at both baseline & follow-up was determined by linear and penalized logistic regression models adjusting for age, lifestyle & demographic, body composition, metabolic, and hormonal factors. Restricted cubic spline analyses was also conducted to capture possible non-linear relationships. At baseline there were positive cross-sectional associations between age (β = 0.409, p<0.001), TT (β = 0.560, p<0.001), fT4 (β = 0.067, p = 0.019) and SHBG, and negative associations between triglycerides (β = -0.112, p<0.001), abdominal fat mass (β = -0.068, p = 0.032) and E2 (β = -0.058, p = 0.050) and SHBG. In longitudinal analysis the positive determinants of SHBG at 4.9 years were age (β = 0.406, p = <0.001), TT (β = 0.461, p = <0.001), and fT4 (β = 0.040, p = 0.034) and negative determinants were triglycerides (β = -0.065, p = 0.027) and abdominal fat mass (β = -0.078, p = 0.032). Taken together these data suggest low SHBG is a marker of abdominal obesity and increased serum triglycerides, conditions which are known to have been associated with low testosterone and low T4.
dc.description.statementofresponsibilityPrabin Gyawali, Sean A. Martin, Leonie K. Heilbronn, Andrew D. Vincent, Alicia J. Jenkins, Andrzej S. Januszewski, Anne W. Taylor, Robert J.T. Adams, Peter D. O'Loughlin, Gary A. Wittert
dc.identifier.citationPLoS ONE, 2018; 13(7):e0200078-1-e0200078-15
dc.identifier.doi10.1371/journal.pone.0200078
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.orcidGyawali, P. [0000-0002-0855-3326]
dc.identifier.orcidHeilbronn, L.K. [0000-0003-2106-7303]
dc.identifier.orcidVincent, A.D. [0000-0002-6428-1070]
dc.identifier.orcidTaylor, A.W. [0000-0002-4422-7974]
dc.identifier.orcidAdams, R.J.T. [0000-0002-7572-0796]
dc.identifier.orcidWittert, G.A. [0000-0001-6818-6065]
dc.identifier.urihttp://hdl.handle.net/2440/114226
dc.language.isoen
dc.publisherPublic Library of Science (PLoS)
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627227
dc.rights© 2018 Gyawali et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.source.urihttps://doi.org/10.1371/journal.pone.0200078
dc.subjectHumans
dc.subjectSex Hormone-Binding Globulin
dc.subjectCohort Studies
dc.subjectLongitudinal Studies
dc.subjectCross-Sectional Studies
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectIndependent Living
dc.subjectBiomarkers
dc.titleCross-sectional and longitudinal determinants of serum sex hormone binding globulin (SHBG) in a cohort of community-dwelling men
dc.typeJournal article
pubs.publication-statusPublished

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