Surface engineered microneedles for delivery of bioactive compounds /
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(Published version)
Date
2021
Authors
Gonzalez Garcia, Laura Elena
Editors
Advisors
Journal Title
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Type:
thesis
Citation
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Abstract
This thesis describes the generation of versatile dissolving microneedle patches with controllable drug release kinetics, antibacterial capability and tailored inflammatory responses that can be used to deliver various types of drug cargoes. Microneedle patches capable of preserving the immunogenicity of a live-attenuated vector vaccines were developed. Self-sterilising capability and possible adjuvant properties were provided by the incorporation of nanosilver. Controlled drug release kinetics was achieved by surface modification using plasma polymer coatings. Different outermost surface chemistries could be used to tailor the body’s immune response by controlling protein adsorption. Further improvement can be achieved by the surface attachment of nanoparticles and therapeutics. Together, the developed microneedle patches can provide bespoke treatment to fit the patients’ needs.
School/Discipline
University of South Australia. UniSA STEM.
UniSA STEM
UniSA STEM
Dissertation Note
Thesis (PhD(Biomaterials Engineering and Nanomedicine))--University of South Australia, 2021.
Provenance
Copyright 2021 Laura Elena González García.
Description
1 ethesis (x, 180 pages, 19 unnumbered pages) :
colour illustrations.
Includes bibliographical references (pages 138-152)
colour illustrations.
Includes bibliographical references (pages 138-152)
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506 0#$fstar $2Unrestricted online access