B-vitamins reduce plasma levels of beta amyloid
Date
2008
Authors
Flickera, L.
Martins, R.
Thomas, J.
Acres, J.
Taddei, K.
Vasikaran, S.
Norman, P.
Jamrozik, K.
Almeida, O.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Neurobiology of Aging, 2008; 29(2):303-305
Statement of Responsibility
Leon Flicker, Ralph N. Martins, Jenny Thomas, John Acres, Kevin Taddei, Samuel D. Vasikaran, Paul Norman, Konrad Jamrozik, Osvaldo P. Almeida
Conference Name
Abstract
Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1–40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD.