New thoughts on the pathobiology of regimen-related mucosal injury

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dc.contributor.authorAnthony, L.
dc.contributor.authorBowen, J.
dc.contributor.authorGarden, A.
dc.contributor.authorHewson, I.
dc.contributor.authorSonis, S.
dc.date.issued2006
dc.description.abstractBackground: Our understanding of the biological basis for mucosal barrier injury (mucositis) induced by cancer therapy with radiation or drugs continues to evolve. A patient’s mucosal response to cancer therapy appears to be controlled by both global (i.e. gender, underlying systemic disease, race) and tissue specific (i.e. epithelial type, intrinsic endocrine system, local microbial environment, function) factors. Conclusion: Interactions of these elements, coupled with underlying genetic influences, most likely govern the risk, course and severity of regimen-related mucosal injury.
dc.description.statementofresponsibilityLowell Anthony, Joanne Bowen, Adam Garden, Ian Hewson, Stephen Sonis
dc.identifier.citationSupportive Care in Cancer, 2006; 14(6):516-518
dc.identifier.doi10.1007/s00520-006-0058-1
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.orcidBowen, J. [0000-0003-0876-0031]
dc.identifier.urihttp://hdl.handle.net/2440/23406
dc.language.isoen
dc.publisherSpringer-Verlag
dc.rights© Springer
dc.source.urihttps://doi.org/10.1007/s00520-006-0058-1
dc.subjectmucosal injury
dc.subjectcancer theraphy
dc.subjectradiation
dc.subjectdrugs
dc.subjectgenetic influences
dc.titleNew thoughts on the pathobiology of regimen-related mucosal injury
dc.typeJournal article
pubs.publication-statusPublished

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