Gastroparesis: prevalence clinical significance and treatment

Simple item page
dc.contributor.authorHorowitz, M.
dc.contributor.authorSu, Y.
dc.contributor.authorRayner, C.
dc.contributor.authorJones, K.
dc.date.issued2001
dc.descriptionCopyright © 2001 Pulsus Group Inc
dc.description.abstractThe application of novel techniques to quantify gastric motor function and gastric emptying has yielded important insights into the prevalence, pathogenesis and clinical sequelae of gastroparesis. Both acute and chronic gastroparesis occur frequently; gastric emptying of solids is delayed in 30% to 50% of patients with diabetes mellitus, functional dyspepsia and gastroesophageal reflux disease. While many patients with gastroparesis experience upper gastrointestinal symptoms that adversely affect quality of life, the concept that symptoms are inevitably the direct outcome of delay in gastric emptying is now recognized to be overly simplistic. In contrast, the potential impact of gastroparesis on oral drug absorption and blood glucose control in patients with diabetes mellitus has probably been underestimated. While the use of prokinetic drugs (cisapride, domperidone, metoclopramide and erythromycin) forms the mainstay of therapy in symptomatic patients with gastroparesis, a number of novel pharmacological therapies are being evaluated, and preliminary studies using gastric pacing show promise.
dc.description.statementofresponsibilityM Horowitz, YC Su, CK Rayner, KL Jones
dc.identifier.citationCanadian Journal of Gastroenterology, 2001; 15(12):805-816
dc.identifier.doi10.1155/2001/628102
dc.identifier.issn0835-7900
dc.identifier.issn2291-2797
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]
dc.identifier.orcidJones, K. [0000-0002-1155-5816]
dc.identifier.urihttp://hdl.handle.net/2440/37058
dc.language.isoen
dc.publisherMedicare Publ Inc
dc.relation.grantNHMRC
dc.source.urihttp://www.pulsus.com/journals/abstract.jsp?sCurrPg=abstract&jnlKy=2&atlKy=5393&isuKy=215&isArt=t
dc.subjectHumans
dc.subjectGastroparesis
dc.subjectMyoelectric Complex, Migrating
dc.subjectGastric Emptying
dc.subjectPostprandial Period
dc.subjectQuality of Life
dc.titleGastroparesis: prevalence clinical significance and treatment
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications