Optoacoustic characterization of prostate cancer in an in vivo transgenic murine model

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dc.contributor.authorPatterson, M.
dc.contributor.authorRiley, C.
dc.contributor.authorKolios, M.
dc.contributor.authorWhelan, W.
dc.date.issued2014
dc.description.abstractOptoacoustic (OA) imaging was employed to distinguish normal from neoplastic tissues in a transgenic murine model of prostate cancer. OA images of five tumor-bearing mice and five age-matched controls across a 14 mm × 14 mm region of interest (ROI) on the lower abdomen were acquired using a reverse-mode OA imaging system (Seno Medical Instruments Inc., San Antonio, Texas). Neoplastic prostate tissue was identified based on the OA signal amplitude in combination with spectral analysis of the OA radio frequency (RF) data. Integration of the signal amplitude images was performed to construct two-dimensional images of the ROI. The prostate tumors generated higher amplitude signals than those of the surrounding tissues, with contrast ratios ranging from 31 to 36 dB. The RF spectrum analysis showed significant differences between the tumor and the control mice. The midband fit was higher by 5 dB (62%), the intercept higher by 4 dB (57%) and the spectral slope higher by 0.4 dB/MHz (50%) for neoplastic prostate tissue compared to normal tissues in the control mice. The results demonstrate that OA offers high contrast imaging of prostate cancer in vivo.
dc.description.statementofresponsibilityMichelle P. Patterson, Christopher B. Riley, Michael C. Kolios, William M. Whelan
dc.identifier.citationJournal of Biomedical Optics, 2014; 19(5):056008-1-056008-8
dc.identifier.doi10.1117/1.JBO.19.5.056008
dc.identifier.issn1083-3668
dc.identifier.issn1560-2281
dc.identifier.urihttp://hdl.handle.net/2440/93457
dc.language.isoen
dc.publisherSPIE
dc.rights© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
dc.source.urihttps://doi.org/10.1117/1.jbo.19.5.056008
dc.subjectPhotoacoustics
dc.subjectprostate cancer
dc.subjectfrequency domain
dc.subjectspectrum Analysis
dc.titleOptoacoustic characterization of prostate cancer in an in vivo transgenic murine model
dc.typeJournal article
pubs.publication-statusPublished

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