Neonatal heel prick mass spectrometry identifies metabolic predictors of AML latency

Simple item page
dc.contributor.authorLim, K.
dc.contributor.authorThompson-Peach, C.
dc.contributor.authorThomas, D.
dc.date.issued2021
dc.description.abstractOngoing research efforts that consider cancer as a disease of dramatically altered cellular metabolism have accelerated interest in snapshot metabolomics in various human tissues. In this issue of Leukemia Research, Petrick et al performed metabolomic analysis on newborn blood spots and found a number of unexpected ceramide and sphingolipid compounds that may play a role in the development and latency of pediatric acute myeloid leukemia (AML). The chemical complexity and range of cellular metabolites massively exceeds the relatively limited building blocks of the transcriptome or the proteome and has high potential to find novel leukemia-specific macromolecular synthesis pathways, metabolic vulnerabilities and biomarkers.
dc.description.statementofresponsibilityKelly Lim, Chloe Thompson-Peach, Daniel Thomas
dc.identifier.citationLeukemia Research, 2021; 109:1-3
dc.identifier.doi10.1016/j.leukres.2021.106644
dc.identifier.issn0145-2126
dc.identifier.issn1873-5835
dc.identifier.orcidLim, K. [0000-0003-4606-7588]
dc.identifier.orcidThompson-Peach, C. [0000-0001-7172-3183]
dc.identifier.urihttps://hdl.handle.net/2440/134791
dc.language.isoen
dc.publisherElsevier
dc.relation.grantNHMRC
dc.rights© 2021 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.leukres.2021.106644
dc.subjectHeel prick; Dried blood spots; Mass spectrometry; Metabolomics; Metabolic predictors; Leukemia; AML
dc.subject.meshHeel
dc.subject.meshHumans
dc.subject.meshNeonatal Screening
dc.subject.meshBlood Specimen Collection
dc.subject.meshInfant, Newborn
dc.subject.meshMass Spectrometry
dc.subject.meshLeukemia, Myeloid, Acute
dc.subject.meshMetabolome
dc.subject.meshBiomarkers, Tumor
dc.titleNeonatal heel prick mass spectrometry identifies metabolic predictors of AML latency
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications