Polycystic ovary syndrome

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dc.contributor.authorNorman, R.
dc.contributor.authorWu, R.
dc.contributor.authorStankiewicz, M.
dc.date.issued2004
dc.descriptionThe document attached has been archived with permission from the editor of the Medical Journal of Australia. An external link to the publisher’s copy is included.
dc.description.abstractPolycystic ovary syndrome (PCOS) affects 5-20% of women of reproductive age worldwide. The condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology (PCOM) - with excessive androgen production by the ovaries being a key feature of PCOS. Metabolic dysfunction characterized by insulin resistance and compensatory hyperinsulinaemia is evident in the vast majority of affected individuals. PCOS increases the risk for type 2 diabetes mellitus, gestational diabetes and other pregnancy-related complications, venous thromboembolism, cerebrovascular and cardiovascular events and endometrial cancer. PCOS is a diagnosis of exclusion, based primarily on the presence of hyperandrogenism, ovulatory dysfunction and PCOM. Treatment should be tailored to the complaints and needs of the patient and involves targeting metabolic abnormalities through lifestyle changes, medication and potentially surgery for the prevention and management of excess weight, androgen suppression and/or blockade, endometrial protection, reproductive therapy and the detection and treatment of psychological features. This Primer summarizes the current state of knowledge regarding the epidemiology, mechanisms and pathophysiology, diagnosis, screening and prevention, management and future investigational directions of the disorder.
dc.description.statementofresponsibilityRobert J Norman, Ruijin Wu and Marcin T Stankiewicz
dc.identifier.citationMedical Journal of Australia, 2004; 180(3):132-137
dc.identifier.doi10.1038/nrdp.2016.57
dc.identifier.issn0025-729X
dc.identifier.issn2056-676X
dc.identifier.orcidNorman, R. [0000-0002-3118-3896]
dc.identifier.urihttp://hdl.handle.net/2440/8369
dc.language.isoen
dc.publisherAustralasian Med Publ Co Ltd
dc.source.urihttp://www.mja.com.au/public/issues/180_03_020204/nor10314_fm.html
dc.subjectOvary
dc.subjectHumans
dc.subjectPolycystic Ovary Syndrome
dc.subjectAcne Vulgaris
dc.subjectHirsutism
dc.subjectAlopecia
dc.subjectObesity
dc.subjectHyperandrogenism
dc.subjectAndrogens
dc.subjectRisk Factors
dc.subjectOvulation
dc.subjectQuality of Life
dc.subjectFemale
dc.titlePolycystic ovary syndrome
dc.typeJournal article
pubs.publication-statusPublished

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