Wild-type MIC distributions and epidemiological cutoff values for Caspofungin and Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document)

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dc.contributor.authorEspinel-Ingroff, A.
dc.contributor.authorFothergill, A.
dc.contributor.authorFuller, J.
dc.contributor.authorJohnson, E.
dc.contributor.authorPelaez, T.
dc.contributor.authorTurnidge, J.
dc.date.issued2011
dc.description.abstractClinical breakpoints have not been established for mold testing. Epidemiologic cutoff values (ECVs) are available for six Aspergillus spp. and the triazoles, but not for caspofungin. Wild-type (WT) minimal effective concentration (MEC) distributions (organisms in a species-drug combination with no acquired resistance mechanisms) were defined in order to establish ECVs for six Aspergillus spp. and caspofungin. The number of available isolates was as follows: 1,691 A. fumigatus, 432 A. flavus, 192 A. nidulans, 440 A. niger, 385 A. terreus, and 75 A. versicolor isolates. CLSI broth microdilution MEC data gathered in five independent laboratories in Canada, Europe, and the United States were aggregated for the analyses. ECVs expressed in µg/ml that captured 95% and 99% of the modeled wild-type population were for A. fumigatus 0.5 and 1, A. flavus 0.25 and 0.5, A. nidulans 0.5 and 0.5, A. niger 0.25 and 0.25, A. terreus 0.25 and 0.5, and A. versicolor 0.25 and 0.5. Although caspofungin ECVs are not designed to predict the outcome of therapy, they may aid in the detection of strains with reduced antifungal susceptibility to this agent and acquired resistance mechanisms.
dc.description.statementofresponsibilityA. Espinel-Ingroff, A. Fothergill, J. Fuller, E. Johnson, T. Pelaez, and J. Turnidge
dc.identifier.citationAntimicrobial Agents and Chemotherapy, 2011; 55(6):2855-2859
dc.identifier.doi10.1128/AAC.01730-10
dc.identifier.issn0066-4804
dc.identifier.issn1098-6596
dc.identifier.orcidTurnidge, J. [0000-0003-4240-5578]
dc.identifier.urihttp://hdl.handle.net/2440/66722
dc.language.isoen
dc.publisherAmer Soc Microbiology
dc.rightsCopyright © 2011, American Society for Microbiology. All Rights Reserved.
dc.source.urihttps://doi.org/10.1128/aac.01730-10
dc.subjectAspergillus
dc.subjectAspergillus fumigatus
dc.subjectAntifungal Agents
dc.subjectMicrobial Sensitivity Tests
dc.subjectEchinocandins
dc.subjectLipopeptides
dc.subjectCaspofungin
dc.titleWild-type MIC distributions and epidemiological cutoff values for Caspofungin and Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document)
dc.typeJournal article
pubs.publication-statusPublished

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