A community-based TB drug susceptibility study in Mimika district, Papua province, Indonesia

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dc.contributor.authorKelly, P.
dc.contributor.authorArdian, M.
dc.contributor.authorWaramori, G.
dc.contributor.authorAnstey, N.
dc.contributor.authorSyahrial, H.
dc.contributor.authorTjitra, E.
dc.contributor.authorBastian, I.
dc.contributor.authorMaguire, G.
dc.contributor.authorLumb, R.
dc.date.issued2006
dc.description.abstractSETTING: A district level tuberculosis (TB) control programme in Papua Province, Indonesia. OBJECTIVE: To determine the nature and extent of drug-resistant TB in newly diagnosed sputum smear-positive patients. METHODS: Sputum was collected from previously untreated smear-positive pulmonary TB patients diagnosed in the district over a 10-month period. Sputum specimens were processed and inoculated into a BACTEC MGIT960 tube. Isolates were identified by Ziehl-Neelsen staining, hybridisation with nucleic acid probes and biochemical investigations. Susceptibility testing was performed using the radiometric proportion method. Pyrazinamide testing was performed using the Wayne indirect method. RESULTS: One hundred and seven patients had sputum sent to a reference laboratory; 101 (94.4%) were culture-positive for Mycobacterium tuberculosis, with 87 (86.1%) fully sensitive to first-line anti-tuberculosis drugs. Two per cent were multidrug-resistant (MDR-TB) and 12 (11.9%) had other drug resistance. Each of the MDR-TB isolates was susceptible to amikacin, capreomycin, ciprofloxacin and para-aminosalicylic acid (PAS), but were resistant to rifabutin. One isolate was also resistant to ethionamide. CONCLUSIONS: MDR-TB is present in Indonesia but is not a major problem for TB control in this district. Generalisability to other districts in Indonesia, particularly large urban areas, needs to be confirmed by future studies.
dc.description.statementofresponsibilityP. M. Kelly, M. Ardian, G. Waramori, N. M. Anstey, H. Syahrial, E. Tjitra, I. Bastian, G. P. Maguire, R. Lumb
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease, 2006; 10(2):167-171
dc.identifier.issn1027-3719
dc.identifier.issn1815-7920
dc.identifier.urihttp://hdl.handle.net/2440/23973
dc.language.isoen
dc.publisherInt Union Against Tuberculosis Lung Disease (i U A T L D)
dc.rights© 2006 Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article
dc.source.urihttp://adelaideaus.library.ingentaconnect.com/content/iuatld/ijtld/2006/00000010/00000002/art00009
dc.subjecttuberculosis
dc.subjectIndonesia
dc.subjectmulti-drug resistance
dc.subjectepidemiology
dc.subjectsurvey
dc.titleA community-based TB drug susceptibility study in Mimika district, Papua province, Indonesia
dc.typeJournal article
pubs.publication-statusPublished

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