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Synthesis and in vitro properties of iron oxide nanoparticles grafted with brushed phosphorylcholine and polyethylene glycol

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dc.contributor.authorBlin, T.
dc.contributor.authorKakinen, A.
dc.contributor.authorPilkington, E.H.
dc.contributor.authorIvask, A.
dc.contributor.authorDing, F.
dc.contributor.authorQuinn, J.F.
dc.contributor.authorWhittaker, M.R.
dc.contributor.authorKe, P.C.
dc.contributor.authorDavis, T.P.
dc.date.issued2016
dc.description.abstractPolyethylene glycol (PEG) is an established grafting agent for engineered materials deployed in aqueous environments including biological systems. Phosphorylcholine (PC) has shown promise as a viable strategy for enhancing the biofunctionality of surfaces and structures. Here we developed a new and facile strategy for grafting superparamagnetic iron oxide nanoparticles (IONPs) by phosphonic acid terminated poly(2-(methacryloyloxy)ethyl phosphorylcholine) brushes, synthetized by reversible addition-fragmentation chain transfer (RAFT) polymerization. Properties of covalently bound IONPs with PC, PEG or PEG:PC brush-like structures via a "grafting onto" approach through robust bidentate Fe-O-P bonds were compared. The presence of modified polymers on the functionalized IONP surfaces was proved using both ATR-FTIR and TGA. The resultant synthesized IONPs were characterized for their physicochemical and biological aspects. Interestingly, compared with PEG combs, specifically, PC brushes rendered comparable or enhanced suspendability, stability, biocompatibility and cellular distribution. We attribute these characteristics to the biomimetic nature and larger polarity of PC in contrast to the synthetic and hydrophilic PEG. These synthesis strategies and characterizations may prove beneficial to the design and applications of IONPs in nanobiotechnology and nanomedicine.
dc.identifier.citationPolymer Chemistry, 2016; 7(10):1931-1944
dc.identifier.doi10.1039/c5py02024g
dc.identifier.issn1759-9954
dc.identifier.issn1759-9962
dc.identifier.urihttps://hdl.handle.net/11541.2/117894
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.fundingARC CE140100036
dc.relation.fundingARC IUT 23-5
dc.relation.fundingARC Australian Laureate Fellowship
dc.rightsCopyright 2016 Royal Society of Chemistry
dc.source.urihttps://doi.org/10.1039/c5py02024g
dc.subjecttransfer radical polymerization
dc.subjectsmall-angle neutron
dc.subjectx-ray-scattering
dc.subjectmagnetic nanoparticles
dc.subjectbiomedical applications
dc.subjectprotein adsorption
dc.subjectsurface-chemistry
dc.subjectphagocytic uptake
dc.subjectparticles
dc.subjectdesign
dc.titleSynthesis and in vitro properties of iron oxide nanoparticles grafted with brushed phosphorylcholine and polyethylene glycol
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916033205001831

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