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Attenuated thermoregulatory response to mild thermal challenge in subjects with sleep-onset insomnia.

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dc.contributor.authorBaulk, S.
dc.contributor.authorBiggs, S.
dc.contributor.authorReid, K.
dc.contributor.authorvan den Heuvel, C.
dc.contributor.authorDrew, D.
dc.date.issued2006
dc.description.abstractSTUDY OBJECTIVES: To determine if heat loss capacity of sleep onset insomniacs was different from that of healthy sleepers. DESIGN: Measure skin temperature responses following brief exposure to a warm peripheral thermal challenge (PTC). SETTING: Sleep research laboratory in South Australia. PARTICIPANTS: Eight primary insomniacs with sleep onset insomnia according to DSM-IV-TR criteria (SOI; 5 male, 3 female; mean age +/- SEM = 35.2 +/- 4.2 years) and ten healthy sleeping control subjects (HS; 7 male, 3 female; mean age = 28.2 +/- 2.8 years). INTERVENTIONS: Two PTC conditions in counterbalanced order on non-consecutive days. During each condition, the subject's non-dominant forearm and hand were immersed for 3 minutes in Warm (45 degrees C) or Control water (i.e. same as the subject's non-dominant index finger temperature just prior to immersion, range 30-35 degrees C). MEASUREMENTS AND RESULTS: HS had a significantly higher maximum finger temperature response after immersion than SOI (P < 0.05). Expressed relative to Control PTC temperatures, the Warm PTC caused a significant increase in mean finger temperature for HS of 4.1 +/- 0.8 degrees C, compared with SOI of 0.9 +/- 0.4 degrees C. A significant negative relationship was observed between maximum finger temperature response and self-reported sleep onset latencies (R = -0.57, P < 0.05). There were no main effects of sleep status (SOI vs. HS) or interactions by time, in skin temperatures measured at either the back of hands or feet. CONCLUSIONS: SOI were observed to have significantly attenuated thermoregulatory responses to a mild positive thermal challenge, providing evidence that impaired heat loss capacity from the periphery is associated with sleep onset insomnia.
dc.description.urihttp://direct.bl.uk/bld/PlaceOrder.do?UIN=195469305&ETOC=RN&from=searchengine
dc.identifier.citationSleep, 2006; 29(9):1174-1180
dc.identifier.doi10.1093/sleep/29.9.1174
dc.identifier.issn0161-8105
dc.identifier.issn1550-9109
dc.identifier.orcidvan den Heuvel, C. [0000-0001-7264-4655]
dc.identifier.urihttp://hdl.handle.net/2440/44603
dc.language.isoen
dc.publisherAmer Academy Sleep Medicine
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.1093/sleep/29.9.1174
dc.subjectNeurological disorder
dc.subjectNervous system diseases
dc.subjectSleep disorder
dc.subjectSleep wake cycle
dc.subjectHuman
dc.subjectInsomnia
dc.subjectSleep
dc.subjectThermoregulation
dc.titleAttenuated thermoregulatory response to mild thermal challenge in subjects with sleep-onset insomnia.
dc.typeJournal article
pubs.publication-statusPublished

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