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Dermal substitutes for clinical management of severe burn injuries: current and future perspectives

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dc.contributor.authorVo, V.
dc.contributor.authorHaidari, H.
dc.contributor.authorCowin, A.J.
dc.contributor.authorWagstaff, M.
dc.contributor.authorDearman, B.
dc.contributor.authorKopecki, Z.
dc.date.issued2025
dc.description.abstractDespite significant advances in recent decades, severe burns remain a formidable challenge, with high morbidity and mortality rates. The immunocompromised state following severe burn injuries, compounded by the loss of the protective skin barrier, increases the risk of bacterial colonization and invasion. Without appropriate management, infections in burn patients can progress to sepsis, a life-threatening complication. Current burn care often fails to achieve optimal tissue regeneration and infection prevention, necessitating a combination of different approaches. Developing innovative and safer strategies to mitigate burn infections is essential for improving patient outcomes. This review provides updated insights into various biomaterials tailored for managing infections in severe burns, offering comprehensive insights and a summary of emerging technologies for potential clinical application. Additionally, an in-depth discussion on current research and clinical areas that warrant further investigation is presented. Potential avenues for next-generation dermal substitutes aimed at improving regeneration and preventing burn wound infections are then explored.
dc.identifier.citationAdvanced Therapeutics, 2025; 8(3, article n. 2400455):1-20
dc.identifier.doi10.1002/adtp.202400455
dc.identifier.issn2366-3987
dc.identifier.issn2366-3987
dc.identifier.orcidCowin, A.J. [0000-0003-2885-2080]
dc.identifier.orcidWagstaff, M. [0000-0003-3160-3720]
dc.identifier.orcidDearman, B. [0000-0001-8804-8401]
dc.identifier.orcidKopecki, Z. [0000-0002-8072-4222]
dc.identifier.urihttps://hdl.handle.net/11541.2/41571
dc.language.isoen
dc.publisherWiley-VCH Verlag GmbH & Co. KGaA
dc.relation.fundingChannel 7 Children's Research Foundation Mid-Career Fellowship
dc.rightsCopyright 2025 The Author(s). Advanced Therapeutics published by Wiley-VCHGmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made (https://creativecommons.org/licenses/by-nc-nd/4.0/) Access Condition Notes: Open access publishing facilitated by University of South Australia, as part of the Wiley - University of South Australia agreement via the Council of Australian University Librarians.
dc.source.urihttps://doi.org/10.1002/adtp.202400455
dc.subjectantimicrobials
dc.subjectbiomaterials
dc.subjectdermal substitutes
dc.subjectsevere burns
dc.subjectwound infections
dc.titleDermal substitutes for clinical management of severe burn injuries: current and future perspectives
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12297955360001831 13303766560001831 Advanced Therapeutics - 2025 - Vo - Dermal Substitutes for Clinical Management of Severe Burn Injuries Current and Future
ror.mmsid9916938235101831

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