Lipoceramic microparticles for enhancing oral anticancer drug delivery /
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(Published version)
Date
2017
Authors
Yuvaraj,Thilagavathi,
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thesis
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Abstract
Lipoceramic (silica-lipid hybrid: SLH) microparticle formulations are solid oral dosage forms that demonstrate excellent drug delivery performance for a number of drugs with low water solubility and poor oral bioavailability (including celecoxib, ibuprofen, indomethacin and itraconazole). SLH is a novel lipid-based nanostructured delivery system identified as a potential strategy for peroral/oral administration of drugs. In this current research project the SLH system is extrapolated to enable oral delivery of the anti-cancer drug SN-38 (currently dosed intravenously) for potential oral chemotherapy. Patients’ prefer oral management in cancer chemotherapy due to its non-harmful procedure, the avoidance of frequent hospital visits and its potential to self-administer. Hence there is interest in the development of oral drug delivery system, which could overcome the current formulation and delivery challenges.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
Dissertation Note
Thesis (PhD(Pharmacy))--University of South Australia, 2017.
Provenance
Copyright 2017 Thilagavathi Yuvaraj.
Description
1 ethesis (xxiv, 147 pages) :
colour illustrations
Includes bibliographical references (pages 127-147)
colour illustrations
Includes bibliographical references (pages 127-147)
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506 0#$fstar $2Unrestricted online access