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Cellular expression of adhesion factors in childhood rhabdomyosarcoma

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dc.contributor.authorSaxon, B.
dc.contributor.authorByard, R.
dc.contributor.authorHan, P.
dc.date.issued1997
dc.description.abstractTumor invasion and metastasis are believed to involve the adhesive interaction of tumor cells with extracellular matrix (ECM). This study reports the expression of laminin, fibronectin, thrombospondin, tenascin, and CD44 in rhabdomyosarcoma cells taken from tumors derived from 12 pediatric patients. Twelve paraffin-embedded rhabdomyosarcomas consisting of five alveolar, six embryonal, and one botryoid subtype were examined. All tumors demonstrated positive staining for tenascin and thrombospondin, 10 were positive for fibronectin, 5 positive for laminin, and 4 positive for CD44. Both specimens without cellular staining for fibronectin were of embryonal subtype and no alveolar rhabdomyosarcomas were positive for CD44. No association of the expression of the studied ECM proteins and receptor with the presence of metastatic disease at clinical presentation or with the level of tumor differentiation was found.
dc.description.statementofresponsibilitySaxon, Benjamin; Byard, Roger ; Han, Ping
dc.identifier.citationPediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association, 1997; 17(2):259-266
dc.identifier.doi10.3109/15513819709168570
dc.identifier.issn1077-1042
dc.identifier.orcidSaxon, B. [0000-0003-1598-5343]
dc.identifier.orcidByard, R. [0000-0002-0524-5942]
dc.identifier.urihttp://hdl.handle.net/2440/5818
dc.language.isoen
dc.publisherTaylor & Francis
dc.source.urihttps://doi.org/10.3109/15513819709168570
dc.subjectHumans
dc.subjectRhabdomyosarcoma
dc.subjectRhabdomyosarcoma, Alveolar
dc.subjectRhabdomyosarcoma, Embryonal
dc.subjectSoft Tissue Neoplasms
dc.subjectMembrane Glycoproteins
dc.subjectCell Adhesion Molecules
dc.subjectThrombospondins
dc.subjectTenascin
dc.subjectRetrospective Studies
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectMale
dc.titleCellular expression of adhesion factors in childhood rhabdomyosarcoma
dc.typeJournal article
pubs.publication-statusPublished

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