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Dietary antioxidants and risk of Barrett's esophagus and adenocarcinoma of the esophagus in an Australian population

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dc.contributor.authorIbiebele, T.I.
dc.contributor.authorHughes, M.C.
dc.contributor.authorNagle, C.M.
dc.contributor.authorBain, C.J.
dc.contributor.authorWhiteman, D.C.
dc.contributor.authorWebb, P.M.
dc.date.issued2013
dc.description.abstractWhile dietary antioxidants are emerging as potentially modifiable risk factors for esophageal adenocarcinoma (EAC), studies on dietary antioxidants and its precursor Barrett's esophagus (BE) are limited. The present study extends previous work on BE by investigating risks of nondysplastic BE, dysplastic BE and EAC associated with intake of antioxidants such as vitamin C, vitamin E, β‐carotene, and selenium. Age and sex matched control subjects (n=577 for BE; n=1,507 for EAC) were sampled from an Australian population register. Information on demography, and well established EAC risk factors were obtained using self‐administered questionnaires. Intake of antioxidants for patients newly diagnosed with nondysplastic BE (n=266), dysplastic BE (n=101), or EAC (n=299), aged 18–79 years, were obtained using a food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable adjusted logistic regression models. High intake of β‐carotene from food and supplement sources combined was inversely associated with risk of dysplastic BE (OR Q4 vs. Q1=0.45; 95%CI: 0.20–1.00). High intake of vitamin E from food sources (OR Q4 vs. Q1=0.43; 95%CI: 0.28–0.67), from food and supplements combined (OR Q4 vs. Q1=0.64; 95%CI: 0.43–0.96), and a high antioxidant index score were inversely associated with risk of EAC. We found no significant trends between intake of β–carotene, vitamin C, vitamin E, and selenium and risk of nondysplastic or dysplastic BE. However, our data suggest that a high intake of β‐carotene may be associated with decreased risk of dysplastic BE.
dc.description.statementofresponsibilityTorukiri I. Ibiebele, Maria Celia Hughes, Christina M. Nagle, Christopher J. Bain, David C. Whiteman, Penelope M. Webb for the Study of Digestive Health and Australian Cancer Study
dc.identifier.citationInternational Journal of Cancer, 2013; 133(1):214-224
dc.identifier.doi10.1002/ijc.28016
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttp://hdl.handle.net/2440/118402
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/199600
dc.rightsCopyright © 2013 UICC.
dc.source.urihttps://doi.org/10.1002/ijc.28016
dc.subjectDietary antioxidants; antioxidant index score; nondysplastic Barrett's esophagus; dysplastic Barrett's esophagus; esophageal adenocarcinoma
dc.titleDietary antioxidants and risk of Barrett's esophagus and adenocarcinoma of the esophagus in an Australian population
dc.typeJournal article
pubs.publication-statusPublished

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