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Cohort profile: why do people keep hurting their back?

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dc.contributor.authorKlyne, D.M.
dc.contributor.authorvan den Hoorn, W.
dc.contributor.authorBarbe, M.F.
dc.contributor.authorCholewicki, J.
dc.contributor.authorMHall, L.
dc.contributor.authorKhan, A.
dc.contributor.authorMeroni, R.
dc.contributor.authorMoseley, G.
dc.contributor.authorNicholas, M.
dc.contributor.authorO'Sullivan, L.
dc.contributor.authorPark, R.
dc.contributor.authorRussell, G.
dc.contributor.authorSterling, M.
dc.contributor.authorHodges, P.W.
dc.date.issued2020
dc.description.abstractObjective Low back pain (LBP) is one of the most disabling and costly conditions worldwide. It remains unclear why many individuals experience persistent and recurrent symptoms after an acute episode whereas others do not. A longitudinal cohort study was established to address this problem. We aimed to; (1) evaluate whether promising and potentially modifiable biological, psychological, social and behavioural factors, along with their possible interactions, predict LBP outcome after an acute episode; (2) compare these factors between individuals with and without acute LBP; and (3) evaluate the time-course of changes in these factors from LBP onset. This paper outlines the methodology and compares baseline characteristics between acute LBP and control, and LBP participants with and without follow-up. Results 133 individuals with acute LBP and 74 pain-free individuals participated. Bio-psycho-social and behavioural measures were collected at baseline and 3-monthly for 12 months (LBP) or 3 months (control). Pain and disability were recorded fortnightly. Baseline characteristics were mostly similar between those who did and did not return for follow-up. Initial analyses of this cohort have revealed important insights into the pathways involved in acute-to-chronic LBP. These and future findings will provide new targets for treatment and prevention of persistent and recurrent LBP.
dc.identifier.citationBMC Research Notes, 2020; 13(1, article no. 538):1-14
dc.identifier.doi10.1186/s13104-020-05356-z
dc.identifier.issn1756-0500
dc.identifier.issn1756-0500
dc.identifier.urihttps://hdl.handle.net/11541.2/146584
dc.language.isoen
dc.publisherBioMed Central
dc.relation.fundingNHMRC 631369
dc.relation.fundingNHMRC 1002489
dc.relation.fundingNHMRC 1091302
dc.relation.fundingNHMRC 1102905
dc.relation.fundingNHMRC 1061279
dc.rightsCopyright 2020 The author(s). . This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made (https://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.1186/s13104-020-05356-z
dc.subjectlow back pain (LBP)
dc.subjectacute to chronic
dc.subjectbiological factors
dc.subjectpsychological factors
dc.subjectsocial factors
dc.subjectbehavioural factors
dc.titleCohort profile: why do people keep hurting their back?
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12214916890001831 13214905760001831 s13104-020-05356-z.pdf
ror.mmsid9916493905201831

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