'Listening' and 'talking' to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids

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dc.contributor.authorWatkins, L.
dc.contributor.authorHutchinson, M.
dc.contributor.authorMilligan, E.
dc.contributor.authorMaier, S.
dc.date.issued2007
dc.descriptionCopyright © 2007 Elsevier B.V. All rights reserved.
dc.description.abstractt is recently become clear that activated immune cells and immune-like glial cells can dramatically alter neuronal function. By increasing neuronal excitability, these non-neuronal cells are now implicated in the creation and maintenance of pathological pain, such as occurs in response to peripheral nerve injury. Such effects are exerted at multiple sites along the pain pathway, including at peripheral nerves, dorsal root ganglia, and spinal cord. In addition, activated glial cells are now recognized as disrupting the pain suppressive effects of opioid drugs and contributing to opioid tolerance and opioid dependence/withdrawal. While this review focuses on regulation of pain and opioid actions, such immune–neuronal interactions are broad in their implications. Such changes in neuronal function would be expected to occur wherever immune-derived substances come in close contact with
dc.description.statementofresponsibilityLinda R. Watkins, Mark R. Hutchinson, Erin D. Milligan and Steven F. Maier
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/506049/description#description
dc.identifier.citationBrain Research Reviews, 2007; 56(1):148-169
dc.identifier.doi10.1016/j.brainresrev.2007.06.006
dc.identifier.issn0165-0173
dc.identifier.issn1872-6321
dc.identifier.orcidHutchinson, M. [0000-0003-2154-5950]
dc.identifier.urihttp://hdl.handle.net/2440/44526
dc.language.isoen
dc.publisherElsevier Science BV
dc.source.urihttps://doi.org/10.1016/j.brainresrev.2007.06.006
dc.subjectNeurophatic pain
dc.subjectMorphine
dc.subjectTolerance
dc.subjectDependence/withdrawal
dc.subjectInterleukin
dc.subjectCytokines
dc.subjectGlia
dc.subjectMicroglia
dc.subjectAstrocytes
dc.subjectDorsal root ganglia
dc.subjectPeripheral nerves
dc.subjectSpinal cord
dc.title'Listening' and 'talking' to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids
dc.typeJournal article
pubs.publication-statusPublished

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