Turn me on: regulating HIF transcriptional activity

Simple item page
dc.contributor.authorLisy, K.
dc.contributor.authorPeet, D.
dc.date.issued2008
dc.description.abstractThe hypoxia-inducible factors (HIFs) are critical for cellular adaptation to limiting oxygen and regulate a wide array of genes when cued by cellular oxygen-sensing mechanisms. HIF is able to direct transcription from either of two transactivation domains, each of which is regulated by distinct mechanisms. The oxygen-dependent asparaginyl hydroxylase factor-inhibiting HIF-1 (FIH-1) is a key regulator of the HIF C-terminal transactivation domain, and provides a direct link between oxygen sensation and HIF-mediated transcription. Additionally, there are phosphorylation and nitrosylation events reported to modulate HIF transcriptional activity, as well as numerous transcriptional coactivators and other interacting proteins that together provide cell and tissue specificity of HIF target gene regulation.
dc.description.statementofresponsibilityK Lisy and D J Peet
dc.identifier.citationCell Death and Differentiation, 2008; 15(4):642-649
dc.identifier.doi10.1038/sj.cdd.4402315
dc.identifier.issn1350-9047
dc.identifier.issn1476-5403
dc.identifier.orcidLisy, K. [0000-0003-2604-4290]
dc.identifier.orcidPeet, D. [0000-0002-6085-8936]
dc.identifier.urihttp://hdl.handle.net/2440/51669
dc.language.isoen
dc.publisherNature Publishing Group
dc.source.urihttps://doi.org/10.1038/sj.cdd.4402315
dc.subjectHIF
dc.subjecthypoxia
dc.subjecttranscription
dc.subjectFIH-1
dc.subjectoxygen
dc.titleTurn me on: regulating HIF transcriptional activity
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Molecular and Biomedical Science publications