Systolic orthostatic hypotension is related to lowered cognitive function: findings from the Maine-Syracuse Longitudinal Study
Date
2017
Authors
Torres, R.V.
Elias, M.F.
Crichton, G.E.
Dore, G.A.
Davey, A.
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Journal article
Citation
The Journal of Clinical Hypertension, 2017; 19(12):1357-1365
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Abstract
The aim of the present study was to examine the relationship between orthostatic changes in blood pressure (BP) and cognition, with consideration given to cardiovascular risk factors and lifestyle variables. The cross-sectional analysis included 961 community-dwelling participants of the Maine-Syracuse Longitudinal Study, for whom BP clinic measures (five sitting, five recumbent, and five standing) were obtained. Eighteen percent of participants had orthostatic hypotension (fall in systolic BP ≥20 mm Hg or diastolic BP ≥10 mm Hg upon standing) and 6% had orthostatic hypertension (rise in systolic BP ≥20 mm Hg). Orthostatic hypotension and hypertension defined using traditional criteria were unrelated to cognition with covariate adjustment. However, an examination of systolic and diastolic BP change independently revealed that participants with systolic orthostatic hypotension had poorer global cognition, verbal memory, and scanning and tracking scores than those with normal systolic BP change. The authors conclude that systolic orthostatic hypotension is significantly associated with reduced cognitive function.
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Data source: Supporting Information, http://onlinelibrary.wiley.com/store/10.1111/jch.13095/asset/supinfo/jch13095-sup-0001-Supinfo.docx?v=1&s=eb2187368672a618115d5c7484336f0cdd56a9bb
Link to a related website: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722679, Open Access via Unpaywall
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Copyright 2017 Wiley Periodicals