Zinc protects against arsenic induced apoptosis in a neuronal cell line, measured by DEVD-caspase activity

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dc.contributor.authorMilton, A.
dc.contributor.authorZalewski, P.
dc.contributor.authorRatnaike, R.
dc.date.issued2004
dc.descriptionThe original publication is available at www.springerlink.com
dc.description.abstractAcute and chronic arsenic exposure results in toxicity in humans and causes many neurological and other manifestations. For the first time the present study reports that zinc decreases arsenic-induced apoptosis and also confirms a single report of apoptosis induced by arsenic in a neuronal cell line. Apoptosis measured by DEVD-caspase activity peaked between 10 M and 20 M of arsenic trioxide. Higher concentrations of arsenic up to 40 M caused increasing cell death with diminishing DEVD-caspase activity. The beneficial effect of zinc was proportional to its concentration with a significant decrease in arsenic-induced DEVD-caspase activity at 50 M and 75 M zinc (P<0.05). This finding may be of therapeutic benefit in people suffering from chronic exposure to arsenic from natural sources, a global problem especially relevant to millions of people on the Indian subcontinent.
dc.description.statementofresponsibilityAustin Graham Milton, Peter David Zalewski and Ranjit Nihal Ratnaike
dc.identifier.citationBioMetals, 2004; 17(6):707-713
dc.identifier.doi10.1007/s10534-004-1210-3
dc.identifier.issn0966-0844
dc.identifier.issn1572-8773
dc.identifier.orcidZalewski, P. [0000-0001-5196-2611]
dc.identifier.urihttp://hdl.handle.net/2440/9824
dc.language.isoen
dc.publisherKluwer Academic Publ
dc.source.urihttps://doi.org/10.1007/s10534-004-1210-3
dc.subjectNeurons
dc.subjectCell Line
dc.subjectAnimals
dc.subjectMice
dc.subjectArsenicals
dc.subjectOxides
dc.subjectZinc
dc.subjectZinc Sulfate
dc.subjectSodium Oxybate
dc.subjectCaspases
dc.subjectEnzyme Inhibitors
dc.subjectApoptosis
dc.subjectEnzyme Activation
dc.subjectDose-Response Relationship, Drug
dc.subjectPhenotype
dc.subjectTime Factors
dc.subjectArsenic Trioxide
dc.titleZinc protects against arsenic induced apoptosis in a neuronal cell line, measured by DEVD-caspase activity
dc.typeJournal article
pubs.publication-statusPublished

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