Current studentsExisting staffContact us
 

The evolution of lncRNA repertoires and expression patterns in tetrapods

Simple item page
dc.contributor.authorNecsulea, A.
dc.contributor.authorSoumillon, M.
dc.contributor.authorWarnefors, M.
dc.contributor.authorLiechti, A.
dc.contributor.authorDaish, T.
dc.contributor.authorZeller, U.
dc.contributor.authorBaker, J.
dc.contributor.authorGrutzner, F.
dc.contributor.authorKaessmann, H.
dc.date.issued2014
dc.descriptionPublished online 19 January 2014
dc.description.abstractOnly a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative analyses. Here we present a large-scale evolutionary study of lncRNA repertoires and expression patterns, in 11 tetrapod species. We identify approximately 11,000 primate-specific lncRNAs and 2,500 highly conserved lncRNAs, including approximately 400 genes that are likely to have originated more than 300 million years ago. We find that lncRNAs, in particular ancient ones, are in general actively regulated and may function predominantly in embryonic development. Most lncRNAs evolve rapidly in terms of sequence and expression levels, but tissue specificities are often conserved. We compared expression patterns of homologous lncRNA and protein-coding families across tetrapods to reconstruct an evolutionarily conserved co-expression network. This network suggests potential functions for lncRNAs in fundamental processes such as spermatogenesis and synaptic transmission, but also in more specific mechanisms such as placenta development through microRNA production.
dc.description.statementofresponsibilityAnamaria Necsulea, Magali Soumillon, Maria Warnefors, Angélica Liechti, Tasman Daish, Ulrich Zeller, Julie C. Baker, Frank Grützner and Henrik Kaessmann
dc.identifier.citationNature, 2014; 505(7485):635-640
dc.identifier.doi10.1038/nature12943
dc.identifier.issn0028-0836
dc.identifier.issn1476-4687
dc.identifier.orcidGrutzner, F. [0000-0002-3088-7314]
dc.identifier.urihttp://hdl.handle.net/2440/86759
dc.language.isoen
dc.publisherNature Publishing Group
dc.rights© 2014 Macmillan Publishers Limited. All rights reserved.
dc.source.urihttps://doi.org/10.1038/nature12943
dc.subjectAnimals
dc.subjectAnura
dc.subjectChickens
dc.subjectPrimates
dc.subjectHumans
dc.subjectMice
dc.subjectProteins
dc.subjectMicroRNAs
dc.subjectRNA Precursors
dc.subjectGenomics
dc.subjectEvolution, Molecular
dc.subjectGene Expression Regulation, Developmental
dc.subjectConserved Sequence
dc.subjectMultigene Family
dc.subjectTranscriptome
dc.subjectRNA, Long Noncoding
dc.titleThe evolution of lncRNA repertoires and expression patterns in tetrapods
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Molecular and Biomedical Science publications