Optical sensors based on whispering gallery modes in fluorescent microbeads: response to specific interactions
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(Published version)
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2010
Authors
Himmelhaus, M.
Krishnamoorthy, S.
François, A.
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Sensors, 2010; 10(6):6257-6274
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Michael Himmelhaus, Sivashankar Krishnamoorthy and Alexandre Francois
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Abstract
Whispering gallery modes (WGMs) in surface-fixated fluorescent polystyrene microbeads are studied in view of their capability of sensing the formation of biochemical adsorption layers on their outer surface with the well-established biotin-streptavidin specific binding as the model system. Three different methods for analysis of the observed shifts in the WGM wavelength positions are applied and used to quantify the adsorbed mass densities, which are then compared with the results of a comparative surface plasmon resonance (SPR) study.
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© 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).