Circadian regulation of reproduction: From gamete to offspring

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dc.contributor.authorBoden, M.
dc.contributor.authorVarcoe, T.
dc.contributor.authorKennaway, D.
dc.date.issued2013
dc.descriptionP01326625; Grants: GNT0519315
dc.description.abstractFew challenges are more critical to the survival of a species than reproduction. To ensure reproductive success, myriad aspects of physiology and behaviour need to be tightly orchestrated within the animal, as well as timed appropriately with the external environment. This is accomplished through an endogenous circadian timing system generated at the cellular level through a series of interlocked transcription/translation feedback loops, leading to the overt expression of circadian rhythms. These expression patterns are found throughout the body, and are intimately interwoven with both the timing and function of the reproductive process. In this review we highlight the many aspects of reproductive physiology in which circadian rhythms are known to play a role, including regulation of the estrus cycle, the LH surge and ovulation, the production and maturation of sperm and the timing of insemination and fertilisation. We will also describe roles for circadian rhythms in support of the preimplantation embryo in the oviduct, implantation/placentation, as well as the control of parturition and early postnatal life. There are several key differences in physiology between humans and the model systems used for the study of circadian disruption, and these challenges to interpretation will be discussed as part of this review.
dc.description.statementofresponsibilityM.J. Boden, T.J. Varcoe, D.J. Kennaway
dc.identifier.citationProgress in Biophysics and Molecular Biology, 2013; 113(3):387-397
dc.identifier.doi10.1016/j.pbiomolbio.2013.01.003
dc.identifier.issn0079-6107
dc.identifier.issn1873-1732
dc.identifier.orcidVarcoe, T. [0000-0002-9462-1830]
dc.identifier.orcidKennaway, D. [0000-0002-5864-3514]
dc.identifier.urihttp://hdl.handle.net/2440/81758
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.rights© 2013 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.pbiomolbio.2013.01.003
dc.subjectReproduction
dc.subjectCircadian rhythm
dc.subjectClock genes
dc.subjectFertility
dc.subjectOvary
dc.subjectParturition
dc.titleCircadian regulation of reproduction: From gamete to offspring
dc.typeJournal article
pubs.publication-statusPublished

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