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Protective role of Ashwagandharishta and flax seed oil against maximal electroshock induced seizures in albino rats

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dc.contributor.authorTanna, I.R.
dc.contributor.authorAghera, H.B.
dc.contributor.authorAshok, B.K.
dc.contributor.authorChandola, H.M.
dc.date.issued2012
dc.description.abstractAshwagandharishta, an Ayurvedic classical formulation, is the remedy for Apasmara (epilepsy), Murchha (syncope), Unmada (psychosis), etc. Recent studies in animal models have shown that n-3 PUFAs can raise the threshold of epileptic seizures. The indigenous medicinal plant, called Atasi (Linum usitatissimum Linn.) in Ayurveda, or flax seed, is the best plant source of omega-3 fatty acids. The present study is designed to investigate whether Ashwagandharishta and Atasi taila (flax seed oil) protect against maximal electroshock (MES) seizures in albino rats. Further, a possible protective role of flax seed oil as an adjuvant to Ashwagandharishta in its anticonvulsant activity has also been evaluated in the study. MES seizures were induced for rats and seizure severity was assessed by the duration of hind limb extensor phase. Phenytoin was used as the standard antiepileptic drug for comparison. Both flax seed oil and Ashwagandharishta significantly decreased convulsion phase. Pre-treatment with flax seed oil exhibited significant anticonvulsant activity by decreasing the duration of tonic extensor phase. Contrary to the expectations, pre-treatment with flax seed oil as an adjuvant to Ashwagandharishta failed to decrease the tonic extensor phase; however, it significantly decreased the flexion phase (P < 0.001) and duration of the convulsions (P < 0.05). Both the drugs exhibited an excellent anti-post-ictal depression effect and complete protection against mortality.
dc.identifier.citationPharmacological Research, 2012; 33(1):114-118
dc.identifier.doi10.4103/0974-8520.100327
dc.identifier.issn1043-6618
dc.identifier.urihttps://hdl.handle.net/11541.2/130329
dc.language.isoen
dc.publisherMedknow Publications and Media
dc.rightsCopyright 2012 Medknow Publications and Media
dc.source.urihttps://doi.org/10.4103/0974-8520.100327
dc.subjectantiepileptic
dc.subjectashwagandharishta
dc.subjectflax seed oil
dc.subjectmaximal electroshock seizure
dc.subjectomega-3 fatty acid
dc.titleProtective role of Ashwagandharishta and flax seed oil against maximal electroshock induced seizures in albino rats
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916171190401831

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